Leiden Thrombosis Recurrence Risk Prevention

NARecruitingINTERVENTIONAL
Enrollment

608

Participants

Timeline

Start Date

June 18, 2021

Primary Completion Date

June 1, 2027

Study Completion Date

June 1, 2027

Conditions
Venous ThromboembolismVenous ThrombosesPulmonary EmbolismDeep Vein Thrombosis
Interventions
OTHER

Randomised treatment advice (discontinue vs continue after 3 months)

Randomisation to continue or discontinue anticoagulant therapy in 1:1 ratio stratified on risk category of L-TRRiP and VTE-BLEED score

DIAGNOSTIC_TEST

VTE-BLEED score

Predict bleeding risk during extended anticoagulant treatment (high or low) using the VTE-BLEED score

DIAGNOSTIC_TEST

L-TRRiP score

Predict VTE recurrence risk after anticoagulant discontinuation (high, intermediate or low) using the L-TRRiP score

OTHER

Advise to continue anticoagulant treatment after 3 months

Advise to continue anticoagulant treatment after 3 months for patients with high VTE recurrence and low bleeding risk

OTHER

Advise to discontinue anticoagulant treatment after 3 months

Advise to discontinue anticoagulant treatment after 3 months for patients with low VTE recurrence risk

Trial Locations (19)

2333 ZA

RECRUITING

Leiden University Medical Center, Leiden

Unknown

RECRUITING

Amsterdam Medical Center, location AMC, Amsterdam

RECRUITING

Wilhelmina Ziekenhuis, Assen

RECRUITING

Rode Kruis Ziekenhuis, Beverwijk

RECRUITING

Amphia Ziekenhuis, Breda

RECRUITING

Deventer Ziekenhuis, Deventer

RECRUITING

Nij Smellinghe Ziekenhuis, Drachten

RECRUITING

Ziekenhuis Gelderse Vallei, Ede

RECRUITING

Catharina Ziekenhuis, Eindhoven

RECRUITING

Admiraal de Ruyter Ziekenhuis, Goes

RECRUITING

Groene Hart Ziekenhuis, Gouda

RECRUITING

Martini Ziekenhuis, Groningen

RECRUITING

University Medical Center Groningen, Groningen

RECRUITING

Radboud University Medical Center, Nijmegen

RECRUITING

Ikazia Ziekenhuis, Rotterdam

RECRUITING

Haaglanden Medisch Centrum, The Hague

RECRUITING

HagaZiekenhuis, The Hague

RECRUITING

Diakonessenhuis, Utrecht

RECRUITING

Isala Klinieken, Zwolle

All Listed Sponsors
lead

Leiden University Medical Center

OTHER