Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,835

Participants

Timeline

Start Date

November 7, 2023

Primary Completion Date

January 22, 2027

Study Completion Date

January 22, 2027

Conditions
Chronic Kidney Disease With High Proteinuria
Interventions
DRUG

Zibotentan/Dapagliflozin

Participants will receive zibotentan/dapagliflozin in fixed-dose combination as per the arms they are randomized to

DRUG

Dapagliflozin

Participants will receive dapagliflozin as per the arms they are randomized to

Trial Locations (296)

110

Research Site, Taipei

161

Research Site, Roma

220

Research Site, New Taipei City

333

Research Site, Taoyuan District

710

Research Site, Tainan City

807

Research Site, Kaohsiung City

833

Research Site, Kaohsiung City

1130

Research Site, Vienna

1280

Research Site, Ciudad de Buenos Aires

1478

Research Site, Lørenskog

1501

Research Site, Benoni

1680

Research Site, Sofia

1685

Research Site, Midrand

1827

Research Site, Lenasia

2250

Research Site, Gosford

2730

Research Site, Herlev

3021

Research Site, Reservoir

3073

Research Site, Reservoir

4000

Research Site, Plovdiv

Research Site, Roskilde

4001

Research Site, Plovdiv

4011

Research Site, Stavanger

4092

Research Site, Chatsworth

4131

Research Site, Meadowbrook

4222

Research Site, Southport

4450

Research Site, Durban

5460

Research Site, Alor Star

5800

Research Site, Pleven

6000

Research Site, Perth

Research Site, Stara Zagora

6800

Research Site, Feldkirch

7400

Research Site, Herning

7505

Research Site, Parow

7600

Research Site, Mar del Plata

7925

Research Site, Cape Town

8073

Research Site, Bodø

8200

Research Site, Aarhus

9019

Research Site, Tromsø

9100

Research Site, Aalborg

9300

Research Site, Dobrich

10000

Research Site, Hanoi

10002

Research Site, Taipei

10117

Research Site, Berlin

10126

Research Site, Torino

10330

Research Site, Bangkok

10380

Research Site, Goyang-si

10400

Research Site, Ratchathewi

10700

Research Site, Bangkok

10940

Research Site, Middletown

11490

Research Site, Taipei

12205

Research Site, Albany

14127

Research Site, Orchard Park

15355

Research Site, Ansan-si

16059

Research Site, Bursa

16132

Research Site, Genoa

17007

Research Site, Girona

19464

Research Site, Pottstown

20901

Research Site, Silver Spring

22100

Research Site, Nahariya

22311

Research Site, Alexandria

23606

Research Site, Newport News

24127

Research Site, Bergamo

27004

Research Site, Lugo

27103

Research Site, Winston-Salem

27834

Research Site, Greenville

28041

Research Site, Madrid

28222

Research Site, Majadahonda

28401

Research Site, Wilmington

28412

Research Site, Wilmington

28504

Research Site, Kinston

28546

Research Site, Jacksonville

28562

Research Site, New Bern

28625

Research Site, Statesville

30000

Research Site, Nîmes

30214

Research Site, Fayetteville

30625

Research Site, Hanover

30990

Research Site, Ipoh

31151

Research Site, Cheonan-si

32040

Research Site, Seri Manjung

32204

Research Site, Jacksonville

32545

Research Site, Bad Oeynhausen

32806

Research Site, Orlando

33016

Research Site, Hialeah

33024

Research Site, Hollywood

33126

Research Site, Miami

33165

Research Site, Miami

33435

Research Site, Boynton Beach

34957

Research Site, Jensen Beach

35805

Research Site, Huntsville

37000

Research Site, Tours

37660

Research Site, Kingsport

38039

Research Site, Kayseri

38700

Research Site, La Tronche

40002

Research Site, Khon Kaen

40138

Research Site, Bologna

40705

Research Site, Taichung

41071

Research Site, Seville

41380

Research Site, Kocaeli

41944

Research Site, Daegu

42101

Research Site, Bowling Green

42270

Research Site, Saint-Priest-en-Jarez

43537

Research Site, Maumee

44281

Research Site, Kfar Saba

46010

Research Site, Valencia

46040

Research Site, Kahramanmaraş

48098

Research Site, Troy

48504

Research Site, Flint

48532

Research Site, Flint

49241

Research Site, Busan

49372

Research Site, Petah Tikva

50200

Research Site, Chaingmai

52074

Research Site, Aachen

52621

Research Site, Ramat Gan

54100

Research Site, Adapazarı

55131

Research Site, Mainz

56124

Research Site, Pisa

59100

Research Site, Kuala Lumpur

60042

Research Site, Island Lake

60077

Research Site, Skokie

60521

Research Site, Hinsdale

60616

Research Site, Chicago

61822

Research Site, Champaign

63376

Research Site, City of Saint Peters

67090

Research Site, Strasbourg

68100

Research Site, Mulhouse

70000

Research Site, Ho Chi Minh City

70300

Research Site, Seremban

71100

Research Site, Foggia

71101

Research Site, Shreveport

76015

Research Site, Arlington

76031

Research Site, Rouen

76100

Research Site, Rehovot

77004

Research Site, Houston

77099

Research Site, Houston

77459

Research Site, Missouri City

77584

Research Site, Pearland

78204

Research Site, San Antonio

78207

Research Site, San Antonio

78212

Research Site, San Antonio

78278

Research Site, Ashkelon

78726

Research Site, Austin

79530

Research Site, Rättvik

80002

Research Site, Arvada

80138

Research Site, Napoli

80230

Research Site, Denver

80336

Research Site, München

82110

Research Site, Mazatlán

84115

Research Site, Salt Lake City

85375

Research Site, Sun City West

88200

Research Site, Kota Kinabalu

90010

Research Site, Los Angeles

90110

Research Site, Hat Yai

90255

Research Site, Huntington Park

90720

Research Site, Los Alamitos

91324

Research Site, Northridge

91356

Research Site, Tarzana

91773

Research Site, San Dimas

92392

Research Site, Victorville

93036

Research Site, Oxnard

93309

Research Site, Bakersfield

94070

Research Site, San Carlos

98275

Research Site, Mukilteo

99202

Research Site, Spokane

100029

Research Site, Beijing

102218

Research Site, Beijing

110017

Research Site, New Delhi

110029

Research Site, Delhi

180000

Research Site, Haiphong

200240

Research Site, Shanghai

210009

Research Site, Nanjing

210011

Research Site, Nanjing

214000

Research Site, Wuxi

264000

Research Site, Yantai

310014

Research Site, Hangzhou

315010

Research Site, Ningbo

317000

Research Site, Linhai

325000

Research Site, Wenzhou

337055

Research Site, Pingxiang

361101

Research Site, Xiamen

387001

Research Site, Nadiād

400010

Research Site, Chongqing

410013

Research Site, Changsha

412007

Research Site, Zhuzhou

421001

Research Site, Hengyang

430010

Research Site, Wuhan

510120

Research Site, Guangzhou

510515

Research Site, Guangzhou

515041

Research Site, Shantou

518039

Research Site, Shenzhen

518053

Research Site, Shenzhen

528000

Research Site, Foshan

530022

Research Site, Nanning

560060

Research Site, Bangalore

590010

Research Site, Belagavi

610000

Research Site, Chengdu

610072

Research Site, Chengdu

610500

Research Site, Yibin

618000

Research Site, Deyang

643000

Research Site, Zigong

700000

Research Site, Ho Chi Minh City

710077

Research Site, Xi'an

750004

Research Site, Yinchuan

3109601

Research Site, Haifa

9372212

Research Site, Jerusalem

02915

Research Site, East Providence

C1425AGC

Research Site, Buenos Aires

B7600

Research Site, Mar del Plata

S3000

Research Site, Santa Fe

66073-005

Research Site, Belém

18618-687

Research Site, Botucatu

89227-680

Research Site, Joinville

15090-000

Research Site, São José do Rio Preto

01228-200

Research Site, São Paulo

04012-909

Research Site, São Paulo

04038-031

Research Site, São Paulo

N6A 5A5

Research Site, London

N2T 0C1

Research Site, Waterloo

J4V 2H1

Research Site, Greenfield Park

H4J 1C5

Research Site, Montreal

014010

Research Site, Baotou

06000

Research Site, Nice

01279

Research Site, Dresden

103-0027

Research Site, Chūōku

251-0041

Research Site, Fujisawa-shi

910-8526

Research Site, Fukui-shi

810-0001

Research Site, Fukuoka

810-8563

Research Site, Fukuoka

819-0168

Research Site, Fukuoka

501-6061

Research Site, Hashima-gun

247-0056

Research Site, Kamakura-shi

816-0864

Research Site, Kasuga-shi

332-0012

Research Site, Kawaguchi-shi

802-8555

Research Site, Kitakyushu-shi

806-8501

Research Site, Kitakyusyu-shi

400-8506

Research Site, Kofu

830-0011

Research Site, Kurume-shi

830-8543

Research Site, Kurume-shi

525-8585

Research Site, Kusatsu-shi

607-8062

Research Site, Kyoto

390-8510

Research Site, Matsumoto-shi

153-0061

Research Site, Meguro-ku

108-0073

Research Site, Minatoku

505-8510

Research Site, Minokamo Shi

662-0918

Research Site, Nishinomiya-Shi

662-0971

Research Site, Nishinomiya-shi

831-0016

Research Site, Okawa-shi

550-0006

Research Site, Osaka

559-0012

Research Site, Osaka

323-0022

Research Site, Oyama-shi

385-8558

Research Site, Sakushu

003-0026

Research Site, Sapporo

062-0931

Research Site, Sapporo

980-8574

Research Site, Sendai

340-0015

Research Site, Soka-shi

760-0076

Research Site, Takamatsu

676-0812

Research Site, Takasago-shi

584-0082

Research Site, Tondabayashi-shi

302-0022

Research Site, Toride-shi

279-0001

Research Site, Urayasu

320-8580

Research Site, Utsunomiya

3813 TZ

Research Site, Amersfoort

4818 CK

Research Site, Breda

3318 AT

Research Site, Dordrecht

0450

Research Site, Oslo

32-500

Research Site, Chrzanów

31-156

Research Site, Krakow

31-501

Research Site, Krakow

92-213

Research Site, Lodz

60-354

Research Site, Poznan

26-600

Research Site, Radom

35-055

Research Site, Rzeszów

70-111

Research Site, Szczecin

03-291

Research Site, Warsaw

984 01

Research Site, Lučenec

080 01

Research Site, Prešov

020 01

Research Site, Púchov

048 01

Research Site, Rožňava

07501

Research Site, Trebišov

06591

Research Site, Seoul

120-752

Research Site, Seoul

156-707

Research Site, Seoul

08907

Research Site, L'Hospitalet de Llobregat

413 46

Research Site, Gothenburg

581 85

Research Site, Linköping

141 86

Research Site, Stockholm

751 85

Research Site, Uppsala

06230

Research Site, Ankara

03400

Research Site, Dinar

CF14 4XW

Research Site, Cardiff

DD1 9SY

Research Site, Dundee

G51 4TF

Research Site, Glasgow

EC1A 2BE

Research Site, London

NW3 2QG

Research Site, London

SE5 9RJ

Research Site, London

YO21 8HE

Research Site, York

Unknown

Research Site, Ho Chi Minh City

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY