A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)

PHASE3RecruitingINTERVENTIONAL
Enrollment

340

Participants

Timeline

Start Date

December 31, 2023

Primary Completion Date

September 10, 2026

Study Completion Date

August 18, 2028

Conditions
Essential Thrombocythemia
Interventions
DRUG

Bomedemstat

Oral Capsule

DRUG

Anagrelide

Oral Capsule

DRUG

Busulfan

Oral Tablet

DRUG

Interferon alfa/pegylated interferon alfa 2a/pegylated interferon alfa 2b

Subcutaneous Solution

DRUG

Ruxolitinib

Oral Tablet

Trial Locations (159)

613

ACTIVE_NOT_RECRUITING

Chang Gung Memorial Hospital- Chiayi ( Site 3102), Chiayi City

704

ACTIVE_NOT_RECRUITING

National Cheng Kung University Hospital-Clinical Trial Center ( Site 3105), Tainan City

1088

RECRUITING

Semmelweis Egyetem-Belgyógyászati és Hematológiai Klinika ( Site 0708), Budapest

2025

ACTIVE_NOT_RECRUITING

Aotearoa Clinical Trials ( Site 0050), Auckland

2030

ACTIVE_NOT_RECRUITING

ZAS Cadix ( Site 1200), Antwerp

2050

RECRUITING

Royal Prince Alfred Hospital ( Site 1100), Camperdown

2065

ACTIVE_NOT_RECRUITING

Royal North Shore Hospital ( Site 0003), St Leonards

2170

ACTIVE_NOT_RECRUITING

Liverpool Hospital-Haematology ( Site 0501), Liverpool

2298

ACTIVE_NOT_RECRUITING

Calvary Mater Newcastle ( Site 0505), Waratah

3021

ACTIVE_NOT_RECRUITING

Western Health-Sunshine & Footscray Hospitals-Cancer Services-Cancer Research ( Site 0502), Melbourne

3168

ACTIVE_NOT_RECRUITING

Monash Health-Haematology Research ( Site 0006), Clayton

4032

RECRUITING

Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Haematologia) ( Site 0707), Debrecen

4400

RECRUITING

Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókór-Haematológia osztály ( Site 0706), Nyíregyháza

5000

ACTIVE_NOT_RECRUITING

Royal Adelaide Hospital-Haematology Clinical Trials Unit ( Site 0001), Adelaide

6000

ACTIVE_NOT_RECRUITING

Royal Perth Hospital-Haematology ( Site 0504), Perth

10048

ACTIVE_NOT_RECRUITING

National Taiwan University Hospital ( Site 3101), Taipei

10128

RECRUITING

Ospedale Mauriziano ( Site 0305), Torino

13620

COMPLETED

Seoul National University Bundang Hospital-Hematology ( Site 0605), Seongnam

14263

RECRUITING

Roswell Park Cancer Institute ( Site 3421), Buffalo

15121

ACTIVE_NOT_RECRUITING

Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo ( Site 0034), Alessandria

15706

ACTIVE_NOT_RECRUITING

CHUS - Hospital Clinico Universitario ( Site 0421), Santiago de Compostela

20122

RECRUITING

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico ( Site 2201), Milan

21100

ACTIVE_NOT_RECRUITING

Ospedale di Circolo e Fondazione Macchi Varese ( Site 2200), Varese

22030

RECRUITING

Trakya University Medical Faculty Hospital-Hematology ( Site 3200), Edirne

22908

RECRUITING

University of Virginia ( Site 3422), Charlottesville

23219

RECRUITING

VCU Health Adult Outpatient Pavillion ( Site 3416), Richmond

27157

RECRUITING

Wake Forest Baptist Health-Internal Medicine, Section on Hematology & Oncology ( Site 3400), Winston-Salem

27710

RECRUITING

Duke University Health System (DUHS) ( Site 0016), Durham

28034

ACTIVE_NOT_RECRUITING

Hospital Universitario Ramón y Cajal-Hematology ( Site 2803), Madrid

28041

ACTIVE_NOT_RECRUITING

Hospital Universitario 12 de Octubre ( Site 2806), Madrid

29010

ACTIVE_NOT_RECRUITING

Hospital Universitario Virgen de la Victoria ( Site 0418), Málaga

29425

RECRUITING

Medical University of South Carolina-Hollings Cancer Center ( Site 3426), Charleston

29603

ACTIVE_NOT_RECRUITING

Hospital Costa del Sol-Hematology Service ( Site 0412), Marbella

31033

ACTIVE_NOT_RECRUITING

Istituto Oncologico Veneto IRCCS-Oncoematologia ( Site 0306), Castelfranco Veneto

33305

ACTIVE_NOT_RECRUITING

Chang Gung Medical Foundation-Linkou Branch ( Site 3103), Taoyuan District

33440

RECRUITING

VM Medical Park Mersin Hastanesi ( Site 3208), Mersin

34214

RECRUITING

Medipol Mega Universite Hastanesi-oncology ( Site 3203), Istanbul

35000

RECRUITING

Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou ( Site 0417), Rennes

35100

RECRUITING

Ege Universitesi Hastanesi ( Site 3202), Izmir

37000

RECRUITING

Centre Hospitalier Régional Universitaire de Tours - Hôpital-Hématologie et Thérapie Cellulaire ( Site 0413), Tours

37007

COMPLETED

Hospital Universitario de Salamanca - Complejo Asistencial U-Servicio de Hematologia ( Site 0419), Salamanca

41380

RECRUITING

Kocaeli Üniversitesi-Hematology ( Site 3205), Kocaeli

42123

RECRUITING

Arcispedale Santa Maria Nuova ( Site 0301), Reggio Emilia

44124

ACTIVE_NOT_RECRUITING

Azienda Ospedaliero Universitaria di Ferrara ( Site 0304), Cona

46017

ACTIVE_NOT_RECRUITING

Hospital Universitario Doctor Peset ( Site 0411), Valencia

47014

ACTIVE_NOT_RECRUITING

"IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori ( Site 0308)", Meldola

48109

RECRUITING

University of Michigan ( Site 0008), Ann Arbor

48202

RECRUITING

Henry Ford Hospital ( Site 3413), Detroit

50134

ACTIVE_NOT_RECRUITING

Azienda Ospedaliera Universitaria Careggi ( Site 0030), Florence

52074

RECRUITING

Universitätsklinikum Aachen ( Site 1801), Aachen

54511

RECRUITING

Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois-HEMATOLOGY ( Site 0407), Vandœuvre-lès-Nancy

55270

RECRUITING

Ondokuz Mayıs Universitesi-hematology ( Site 3206), Samsun

56126

RECRUITING

Azienda Ospedaliero Universitaria Pisana-UO Ematologia UNIV ( Site 0309), Pisa

59100

RECRUITING

Centre Hospitalier de Roubaix ( Site 1703), Roubaix

60126

RECRUITING

Azienda Ospedaliero Universitaria delle Marche ( Site 0302), Ancona

69310

RECRUITING

centre hospitalier lyon sud ( Site 0406), Pierre-Bénite

75010

RECRUITING

Hôpital Saint-Louis-Centre d'Investigations Cliniques ( Site 0405), Paris

75571

COMPLETED

Hôpital Saint Antoine-Service d'Hématologie et de Thérapie Cellulaire ( Site 1702), Paris

80045

RECRUITING

University of Colorado Anschutz Medical Campus ( Site 3425), Aurora

83301

ACTIVE_NOT_RECRUITING

Chang Gung Memorial Hospital at Kaohsiung-Division of Hematology and Oncology ( Site 3104), Kaohsiung City

87042

RECRUITING

Centre Hospitalier Universitaire de Limoges - Hôpital Dupuyt-Hématologie Clinique et Thérapie Cellu ( Site 1701), Limoges

90502

RECRUITING

The Lundquist Institute ( Site 3423), Torrance

91206

RECRUITING

Los Angeles Cancer Network ( Site 3491), Glendale

100191

RECRUITING

Peking University Third Hospital-Hematology ( Site 3502), Beijing

100730

RECRUITING

Peking Union Medical College Hospital ( Site 3531), Beijing

110121

ACTIVE_NOT_RECRUITING

Los Cobos Medical Center ( Site 1404), Bogotá

130021

COMPLETED

The First Hospital of Jilin University-Hematology ( Site 3526), Changchun

200032

RECRUITING

Zhongshan Hospital,Fudan University-Hematology ( Site 3530), Shanghai

200040

RECRUITING

Huashan Hospital, Fudan University ( Site 3529), Shanghai

210029

ACTIVE_NOT_RECRUITING

Jiangsu Province Hospital ( Site 3507), Nanjing

226001

RECRUITING

Affiliated Hospital of Nantong University ( Site 3527), Nantong

230002

ACTIVE_NOT_RECRUITING

IMAT S.A.S ( Site 1401), Montería

230071

RECRUITING

Anhui Provincial Hospital ( Site 3513), Hefei

233004

RECRUITING

The First Afflilated Hospital of Bengbu Medical College ( Site 3509), Bengbu

250013

RECRUITING

Jinan Central Hospital ( Site 3523), Jinan

300020

RECRUITING

Institute of hematology&blood disease hospital ( Site 3501), Tianjin

310003

RECRUITING

The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 3508), Hangzhou

322000

RECRUITING

Zhejiang University School of Medicine-The Fourth Affiliated Hospital ( Site 3517), Yiwu

330209

RECRUITING

The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 3505), Nanchang

361003

RECRUITING

The First Affiliated hospital of Xiamen University ( Site 3515), Xiamen

362000

RECRUITING

The Second Affiliated Hospital Of Fujian Medical University ( Site 3525), Quanzhou

430022

RECRUITING

Wuhan Union Hospital ( Site 3500), Wuhan

450008

RECRUITING

Henan Cancer Hospital-hematology department ( Site 3504), Zhengzhou

510120

RECRUITING

Sun Yat-sen Memorial Hospital of Sun Yat-sen University ( Site 3524), Guangzhou

510515

RECRUITING

Southern Medical University Nanfang Hospital-Department of Hematopathology ( Site 3511), Guangzhou

610041

RECRUITING

West China Hospital, Sichuan University ( Site 3518), Chengdu

710068

RECRUITING

Shaanxi provincial people's hospital ( Site 3516), Xi'an

3109601

ACTIVE_NOT_RECRUITING

Rambam Health Care Campus ( Site 2102), Haifa

3436212

ACTIVE_NOT_RECRUITING

Carmel Hospital ( Site 0906), Haifa

4941492

RECRUITING

Rabin Medical Center ( Site 0905), Petah Tikva

5265601

ACTIVE_NOT_RECRUITING

Sheba Medical Center ( Site 2101), Ramat Gan

6423906

ACTIVE_NOT_RECRUITING

Sourasky Medical Center ( Site 0902), Tel Aviv

7033001

ACTIVE_NOT_RECRUITING

Yitzhak Shamir Medical Center. ( Site 0901), Ẕerifin

8410101

ACTIVE_NOT_RECRUITING

Soroka Medical Center ( Site 2100), Beersheba

9112001

ACTIVE_NOT_RECRUITING

Hadassah Medical Center ( Site 0904), Jerusalem

94305-5826

RECRUITING

Stanford Cancer Institute ( Site 0107), Stanford

02111

RECRUITING

Tufts Medical Center ( Site 3408), Boston

B1629AHJ

RECRUITING

Hospital Universitario Austral ( Site 0104), Pilar

C1199ABB

ACTIVE_NOT_RECRUITING

Hospital Italiano de Buenos Aires ( Site 0105), ABB

T4000IKO

ACTIVE_NOT_RECRUITING

C.I.C.E. 9 de Julio ( Site 1001), San Miguel de Tucumán

E1C 6Z8

RECRUITING

The Moncton Hospital-Oncology ( Site 1500), Moncton

050031

RECRUITING

The First Hospital of Hebei Medical University ( Site 3510), Shijiazhuang

050030

ACTIVE_NOT_RECRUITING

Fundacion Colombiana de Cancerología Clinica Vida ( Site 1403), Medellín

01307

RECRUITING

Universitaetsklinikum Carl Gustav Carus Dresden-Medical Dept I - Medical Oncology ( Site 0402), Dresden

06120

RECRUITING

Universitätsklinikum Halle ( Site 0401), Halle

Unknown

RECRUITING

Queen Mary Hospital ( Site 1901), Hksar

RECRUITING

Petz Aladar Egyetemi Oktato Korhaz ( Site 2000), Győr

470-1192

RECRUITING

Fujita Health University Hospital ( Site 3613), Toyoake

277-8577

RECRUITING

National Cancer Center Hospital East ( Site 3610), Kashiwa

791-0295

RECRUITING

Ehime University Hospital ( Site 3612), Tōon

060-8648

RECRUITING

Hokkaido University Hospital ( Site 3601), Sapporo

650-0047

RECRUITING

Kobe City Medical Center General Hospital ( Site 3603), Kobe

920-8641

RECRUITING

Kanazawa University Hospital ( Site 3614), Kanazawa

514-8507

RECRUITING

Mie University Hospital ( Site 3615), Tsu

983-8520

RECRUITING

National Hospital Organization Sendai Medical Center ( Site 3617), Sendai

573-1191

RECRUITING

Kansai Medical University Hospital ( Site 3607), Hirakata

589-8511

RECRUITING

Kindai University Hospital ( Site 3600), Sayama

113-8431

RECRUITING

Juntendo University Hospital ( Site 3611), Bunkyo-ku

113-8603

RECRUITING

Nippon Medical School Hospital ( Site 3608), Bunkyo-ku

409-3898

RECRUITING

University of Yamanashi Hospital ( Site 3606), Chūō

812-8582

RECRUITING

Kyushu University Hospital ( Site 3605), Fukuoka

960-1295

RECRUITING

Fukushima Medical University Hospital ( Site 3616), Fukushima

889-1692

RECRUITING

University of Miyazaki Hospital ( Site 3609), Miyazaki

700-8558

RECRUITING

Okayama University Hospital ( Site 3604), Okayama

2134 TM

COMPLETED

Spaarne Gasthuis - Hoofddorp-Oncology ( Site 2301), Hoofddorp

3318 AT

ACTIVE_NOT_RECRUITING

Albert Schweitzer Ziekenhuis, locatie Dordwijk-Internal Medicine ( Site 2302), Dordrecht

9700 RB

ACTIVE_NOT_RECRUITING

University Medical Center Groningen ( Site 2304), Groningen

9728 NT

ACTIVE_NOT_RECRUITING

Martini Ziekenhuis ( Site 2300), Groningen

0622

ACTIVE_NOT_RECRUITING

North Shore Hospital-Department of Haematology ( Site 0051), Auckland

40-519

ACTIVE_NOT_RECRUITING

Pratia Onkologia Katowice ( Site 0702), Katowice

25-734

RECRUITING

Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Hematologii i Transplantacji S ( Site 2504), Kielce

4710-243

RECRUITING

Unidade Local de Saude de Braga - Hospital de Braga ( Site 0415), Braga

1449-005

RECRUITING

Unidade Local de Saude Lisboa Ocidental - Hospital de São Francisco Xavier ( Site 2600), Lisbon

4200-072

RECRUITING

Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 0414), Porto

02841

COMPLETED

Korea University Anam Hospital ( Site 0604), Seoul

05505

ACTIVE_NOT_RECRUITING

Asan Medical Center ( Site 0603), Seoul

06591

ACTIVE_NOT_RECRUITING

The Catholic Univ. of Korea Seoul St. Mary's Hospital ( Site 0606), Seoul

08916

ACTIVE_NOT_RECRUITING

Hospital Germans Trias i Pujol-Instituto Catalán de Oncología de Badalona ( Site 0409), Badalona

08908

ACTIVE_NOT_RECRUITING

Institut Català d'Oncologia - L'Hospitalet-Haematology Department ( Site 2801), L'Hospitalet Del Llobregat

08003

ACTIVE_NOT_RECRUITING

Hospital del Mar ( Site 2807), Barcelona

08036

ACTIVE_NOT_RECRUITING

HOSPITAL CLÍNIC DE BARCELONA ( Site 2800), Barcelona

02006

ACTIVE_NOT_RECRUITING

Hospital General Universitario de Albacete ( Site 0408), Albacete

08035

ACTIVE_NOT_RECRUITING

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 0404), Barcelona

141 86

ACTIVE_NOT_RECRUITING

Karolinska Universitetssjukhuset Huddinge ( Site 2900), Huddinge

701 85

ACTIVE_NOT_RECRUITING

Universitetssjukhuset Örebro ( Site 0403), Örebro

06230

RECRUITING

Hacettepe Universite Hastaneleri-Department of Hematology ( Site 3204), Ankara

06620

RECRUITING

Ankara UTF Cebeci Arastırma ve Uygulama Hastanesi ( Site 3210), Ankara

06800

RECRUITING

Ankara Bilkent Şehir Hastanesi ( Site 3201), Ankara

07100

RECRUITING

Antalya Egitim ve Arastırma Hastanesi ( Site 3207), Antalya

CB2 2QQ

ACTIVE_NOT_RECRUITING

Addenbrooke's Hospital ( Site 3303), Cambridge

Gl1 3NN

ACTIVE_NOT_RECRUITING

Gloucestershire Royal Hospital ( Site 3302), Gloucester

LN2 5QY

ACTIVE_NOT_RECRUITING

Lincoln County Hospital ( Site 3310), Lincoln

PE21 9QS

RECRUITING

Boston Pilgrim Hospital ( Site 3301), Boston

NW1 2PG

RECRUITING

University College London Hospital ( Site 3300), London

SE1 9RT

ACTIVE_NOT_RECRUITING

Guy's & St Thomas' NHS Foundation Trust ( Site 3305), London

SE5 9RS

RECRUITING

King's College Hospital ( Site 3308), London

NP20 2UB

ACTIVE_NOT_RECRUITING

Royal Gwent Hospital ( Site 3304), Gwent

SL4 3HD

ACTIVE_NOT_RECRUITING

GenesisCare - Windsor ( Site 3309), Windsor

m20 4bx

RECRUITING

The Christie NHS Foundation Trust ( Site 3307), Manchester

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY