The Impact of Oral Vitamin C in Prevention for Post Operative Atrial Fibrillation (POAF) in Coronary Artery Bypass Surgery (CABG) Patients

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

180

Participants

Timeline

Start Date

October 13, 2020

Primary Completion Date

October 15, 2023

Study Completion Date

October 30, 2023

Conditions
Post Operative Atrial Fibrillation
Interventions
DRUG

Vitamin C 500 MG Oral Capsule(High dose 2g daily)

A sixty CABG patients commenced on maximum tolerated dose of b-blocker, statins \& vitamin C 500 mg (2 g-daily in 4 divided doses) started one day before operation till the end of hospital stay or development of post operative atrial fibrillation

DRUG

Vitamin C 500 MG Oral Capsule(Low-dose 1g daily)

A sixty CABG patients commenced on maximum tolerated dose of b-blocker, statins, vitamin C 500 mg (1 g-daily in 2 divided doses) and also received 2 capsules containing starch to be completely equivalent in frequency to the other groups. the intervention started one day before operation till the end of hospital stay or development of post operative atrial fibrillation.

DRUG

placebo capsules

A sixty CABG Patients commenced on maximum tolerated dose of b-blocker, statins and placebo capsules containing starch mimic vitamin C capsules was taken every 6 hrs. The placebo capsules were prepared in the same shape and size as the original ones manufactured by the same pharmaceutical company. the intervention started one day before operation till the end of hospital stay or development of post operative atrial fibrillation.

Trial Locations (1)

3210001

El Sheik Zayed Specialized Hospital, Giza

All Listed Sponsors
lead

Helwan University

OTHER