The Influence of Feeding Source on the Gut Microbiome and Time to Full Feeds in Neonates With Congenital Gastrointestinal Pathologies

NARecruitingINTERVENTIONAL
Enrollment

116

Participants

Timeline

Start Date

June 9, 2023

Primary Completion Date

June 9, 2025

Study Completion Date

June 9, 2025

Conditions
Gastrointestinal ComplicationIntestinal ObstructionGastroschisisHirschsprung DiseaseOmphaloceleMidgut Volvulus
Interventions
DIETARY_SUPPLEMENT

Standard of Care

Standard of care arm: Mothers will consent to providing DHM (if qualifies per hospital policy) or formula if MOM is not available. Infants are only eligible to receive donor milk only if 1) MOM is not available 2) if infant initiates feeds before day 3 of age. The donor milk feed would be stopped on day 5 of age.

DIETARY_SUPPLEMENT

Exclusive Human Milk

Mothers will consent to providing DHM if MOM is not available. If the infant reaches 100 ml/kg/day of feeds (one feed advancement prior to full feeds) and MOM remains unavailable, they will transition to formula in preparation for discharge. Infants cannot be discharged on donor milk.

Trial Locations (1)

98105

RECRUITING

Seattle Children's Hospital, Seattle

All Listed Sponsors
lead

Seattle Children's Hospital

OTHER