A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

270

Participants

Timeline

Start Date

March 18, 2024

Primary Completion Date

October 15, 2028

Study Completion Date

February 9, 2031

Conditions
Low Grade Serous Ovarian Cancer
Interventions
DRUG

avutometinib

Avutometinib: administered orally

DRUG

Defactinib

Defactinib: administered orally

DRUG

Pegylated liposomal doxorubicin

administered intravenously

DRUG

Paclitaxel

administered intravenously

DRUG

Letrozole

administered orally

DRUG

Anastrozole

administered orally

Trial Locations (103)

1023

RECRUITING

Auckland City Hospital, Auckland

1066

RECRUITING

Netherlands Cancer Insitute, Amsterdam

2031

RECRUITING

Prince of Wales Hospital, Randwick

2650

RECRUITING

UZA, Edegem

3000

RECRUITING

Peter MacCallum Cancer Centre, Melbourne

4066

RECRUITING

Icon Cancer Centre Wesley, Auchenflower

5000

RECRUITING

Cancer Research South Australia, Adelaide

6009

RECRUITING

Sir Charles Gairdner Hospital, Nedlands

9000

RECRUITING

University Hospital Ghent, Ghent

RECRUITING

Aalborg U.H, Aalborg

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10128

RECRUITING

S.C.D.U. Oncologia, Torino

13353

RECRUITING

Charité - Universitätsmedizin Berlin, Berlin

13620

RECRUITING

Seoul National University Bundang Hospital, Seongnam

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

15224

RECRUITING

Allegheny Health Network, Pittsburgh

15706

RECRUITING

Hospital Clínico Universitario de Santiago, Santiago de Compostela

20014

RECRUITING

H. de Donostia, Donostia / San Sebastian

20132

RECRUITING

San Raffaele Hospital, Milan

20133

RECRUITING

Istituto Nazionale dei Tumori, Milan

20155

RECRUITING

Virginia Cancer Specialists, PC, Gainesville

20159

RECRUITING

Humanitas San Pio X, Milan

20246

RECRUITING

UMC Hamburg-Eppendorf, Hamburg

21079

RECRUITING

Site Georges François Leclerc, Dijon

21287

RECRUITING

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

22908

RECRUITING

University of Virginia Health System, Charlottesville

25000

RECRUITING

Centre Hospitalier de Besançon, Besançon

25123

RECRUITING

Spedali Civili, Brescia

28203

RECRUITING

Atrium Health, Charlotte

30120

RECRUITING

Clínico Virgen de La Arrixaca, El Palmar

30322

RECRUITING

Winship Cancer Institute at Emory University, Atlanta

32804

RECRUITING

AdventHealth, Orlando

33081

RECRUITING

Centro di Riferimento Oncologico (CRO), Aviano

33140

RECRUITING

Mount Sinai, Miami Beach

33401

RECRUITING

Florida Cancer Specialists Research East, West Palm Beach

33612

RECRUITING

Moffitt Cancer Center, Tampa

33901

RECRUITING

Florida Cancer Specialists - South, Fort Myers

35128

RECRUITING

Istituto Oncologico Veneto (IOV), Padua

43026

RECRUITING

Ohio State, Hilliard

44195

RECRUITING

Cleveland Clinic Foundation, Cleveland

45136

RECRUITING

Kliniken Essen-Mitte, Essen

46010

RECRUITING

Hospital Clínico Universitario de Valencia, Valencia

48201

RECRUITING

Karmanos Cancer Center, Detroit

55404

RECRUITING

Minnesota Oncology Hematology, Minneapolis

59020

RECRUITING

Centre Oscar Lambret, Lille

60201

RECRUITING

NorthShore University HealthSystem, Evanston

60431

RECRUITING

Agaplesion Markus Krankenhaus, Frankfurt am Main

63110

RECRUITING

Washington University School of Medicine, St Louis

68167

RECRUITING

Universitätsklinikum Mannheim GmbH, Mannheim

69373

RECRUITING

Centre Léon Bérard, Lyon

70112

RECRUITING

Louisiana State University, New Orleans

72205

RECRUITING

University of Arkansas, Little Rock

73104

RECRUITING

University of Oklahoma Medical Center, Oklahoma City

75702

RECRUITING

Texas Oncology, Tyler

76104

RECRUITING

Texas Oncology-Fort Worth Cancer Center, Fort Worth

77030

RECRUITING

Houston Methodist, Houston

RECRUITING

MD Anderson Cancer Center, Houston

77380

RECRUITING

Texas Oncology, The Woodlands

78229

RECRUITING

Texas Oncology, San Antonio

78731

RECRUITING

Texas Oncology Central, Austin

84107

RECRUITING

Intermountain Medical Center, Murray

85016

RECRUITING

HonorHealth, Phoenix

89075

RECRUITING

Universitätsfrauenkinik Ulm, Ulm

90095

RECRUITING

UCLA Health, Los Angeles

94143

RECRUITING

University of California, San Francisco, San Francisco

95126

RECRUITING

AO Cannizzaro, Catania

95817

RECRUITING

UC Davis, Sacramento

97227

RECRUITING

Northwest Cancer Specialists, Portland

97401

RECRUITING

Willamette Valley Cancer Institute, Eugene

06520

RECRUITING

Yale University, New Haven

Pennsylvania

RECRUITING

"Asplundh Cancer Pavilion , Jefferson Health"

M5G 1X6

RECRUITING

Princess Margaret Cancer Center, Toronto

H2X 0C1

RECRUITING

Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal

H4A 3J1

RECRUITING

McGill University Health Centre, Montreal

V5Z 4E6

RECRUITING

British of Columbia, Vancouver

Unknown

RECRUITING

Institut Curie, Paris

RECRUITING

European Institute of Oncology (IEO), Milan

RECRUITING

INT Napoli Hospital, Napoli

RECRUITING

Osaka Medical Center, Osaka

RECRUITING

H. Vall d´ Hebron, Barcelona

RECRUITING

Hospital Universitario Reina Sofía, Córdoba

RECRUITING

H.U. Ramón y Cajal, Madrid

RECRUITING

University of Edinburgh Cancer Research Centre, Edinburgh

RECRUITING

The Christie NHS Foundation Trust, Manchester

01307

RECRUITING

Universitätsklinikum Carl Gustav Carus, Dresden

08

RECRUITING

St. James's Hospital, Dublin

00168

RECRUITING

IRCCS Gemelli, Roma

00144

RECRUITING

Istituti Fisioterapici Ospitalieri, Rome

514-8507

RECRUITING

The Mie University Hospital, Tsu

6525 GA

RECRUITING

Radboud UMC, Nijmegen

15-027

RECRUITING

Białostockie Centrum Onkologii, Bialystok

80-214

RECRUITING

Gdański Uniwersytet Medyczny, Gdansk

98-110

RECRUITING

Siedleckie Centrum Onkologii, Siedlce

03722

RECRUITING

Yonsei University Severance Hospital, Seoul

05505

RECRUITING

Asan Medical Center, Seoul

06273

RECRUITING

Gangnam Severance Hospital, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

G120YN

RECRUITING

Greater Glasgow and Clyde (GGC), Glasgow

CB2 0QQ

RECRUITING

Cambridge University Hospital, Cambridge

LE2 7LX

RECRUITING

Hope Cancer Trials Centre, Leicester

NW1 2PG

RECRUITING

University College London Hospitals NHS Foundation Trust, London

SW7 3RP

RECRUITING

Royal Marsden Hospital, London

SM2 5PT

RECRUITING

Royal Marsden Hospital, Sutton

All Listed Sponsors
collaborator

GOG Foundation

NETWORK

collaborator

European Network of Gynaecological Oncological Trial Groups (ENGOT)

OTHER

collaborator

Australia New Zealand Gynaecological Oncology Group

OTHER

collaborator

Korean Gynecologic Oncology Group

OTHER

lead

Verastem, Inc.

INDUSTRY