NCT06067269View on ClinicalTrials.gov

Hormone Therapy (Apalutamide) and Image-guided Stereotactic Body Radiation Therapy for the Treatment of Patients With Prostate Cancer, HEATWAVE Trial

PHASE2RecruitingINTERVENTIONAL
Enrollment

95

Participants

Timeline

Start Date

March 28, 2024

Primary Completion Date

December 1, 2026

Study Completion Date

December 1, 2027

Conditions
Prostate AdenocarcinomaStage II Prostate Cancer AJCC v8Stage IIIA Prostate Cancer AJCC v8Stage IIIB Prostate Cancer AJCC v8
Interventions
DRUG

Apalutamide

Given PO

PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

PROCEDURE

Computed Tomography

Undergo PSMA-PET/CT

OTHER

Gallium Ga 68 Gozetotide

Undergo PSMA-PET/CT

RADIATION

Guided Stereotactic Body Radiation Therapy

Undergo guided SBRT

PROCEDURE

Multiparametric Magnetic Resonance Imaging

Undergo multiparametric MRI

PROCEDURE

Positron Emission Tomography

Undergo PSMA-PET/CT

OTHER

Questionnaire Administration

Ancillary studies

Trial Locations (1)

90095

RECRUITING

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles

All Listed Sponsors
collaborator

Janssen Scientific Affairs, LLC

INDUSTRY

lead

Jonsson Comprehensive Cancer Center

OTHER