Propranolol in Primary Progressive Aphasia

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

January 13, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2027

Conditions
Aphasia, Primary Progressive
Interventions
DRUG

Propranolol

Propranolol will be given on a titration schedule in which participants will begin with small doses of the drug and increase to a larger dosage over the course of three weeks. Propranolol will be taken for a total of 9 weeks.

DEVICE

Magnetic Resonance Imaging (MRI)

Magnetic Resonance Imaging (MRI) will be performed at 3 Tesla and 7 Tesla, for both propranolol and placebo arms.

DRUG

Placebo

Placebo will be given on the same schedule as the propranolol regime.

Trial Locations (1)

65212

RECRUITING

University of Missouri-Columbia, Columbia

All Listed Sponsors
lead

University of Missouri-Columbia

OTHER