Effect of Nutritional Ketosis on Alcohol Metabolism

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

February 29, 2024

Primary Completion Date

December 1, 2025

Study Completion Date

December 1, 2026

Conditions
Ketoses, MetabolicKetogenic DietingAlcohol IntoxicationMagnetic Resonance ImagingAlcohol Drinking
Interventions
DIETARY_SUPPLEMENT

Ketone Supplement

Ketone supplement 3x day with control diet for 3 days.

OTHER

Control Diet

Control Diet breakfast, lunch, and dinner for 3 days.

OTHER

Ketogenic diet

Ketogenic Diet breakfast, lunch, and dinner for 3 days.

DRUG

Ethanol

After 3 days of diet intervention, participants will receive alcohol drinks that dose-adjusts for body weight and sex differences in pharmacokinetics and calculated to obtain a final breath alcohol concentration of 0.08%

Trial Locations (1)

19104

RECRUITING

University of Pennsylvania Center for Studies of Addiction, Philadelphia

All Listed Sponsors
collaborator

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NIH

lead

University of Pennsylvania

OTHER