988
Participants
Start Date
February 22, 2024
Primary Completion Date
December 31, 2026
Study Completion Date
December 31, 2027
Metformin pretreatment before ovarian stimulation
The enrolled patients will be prescribed metformin 850mg twice daily for at least 4 weeks prior to ovarian stimulation till oocyte retrieval.
Placebo pretreatment before ovarian stimulation
The enrolled patients will be prescribed placebo 850mg twice daily for at least 4 weeks prior to ovarian stimulation till oocyte retrieval.
Metformin pretreatment before endometrial preparation for frozen embryo transfer
After oocyte retrieval, the enrolled patients will be prescribed metformin 850mg twice daily for at least 4 weeks before endometrial preparation for frozen embryo transfer and till the establishment of clinical pregnancy (7-8 weeks gestation) after the first frozen embryo transfer.
Placebo pretreatment before endometrial preparation for frozen embryo transfer
After oocyte retrieval, the enrolled patients will be prescribed placebo 850mg twice daily for at least 4 weeks before endometrial preparation for frozen embryo transfer and till the establishment of clinical pregnancy (7-8 weeks gestation) after the first frozen embryo transfer.
RECRUITING
Shandong University, Jinan
Collaborators (1)
Ren Ji Hospital of Shanghai Jiao Tong University
UNKNOWN
Women's Hospital of Zhejiang University
UNKNOWN
Shengjing Hospital
OTHER
Nanjing Medical University
OTHER
General Hospital of Ningxia Medical University
OTHER
West China Second University Hospital
OTHER
Maternal and Child Health Hospital of Henan Province
UNKNOWN
Qingdao women's and children's Hospital
UNKNOWN
Shandong University
OTHER