A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

PHASE2RecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

June 25, 2024

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Stage II Nasopharyngeal Carcinoma AJCC v8Stage III Nasopharyngeal Carcinoma AJCC v8Stage IV Nasopharyngeal Carcinoma AJCC v8
Interventions
PROCEDURE

Biopsy Procedure

Undergo tissue biopsy

PROCEDURE

Biospecimen Collection

Undergo blood and stool sample collection

PROCEDURE

Chest Radiography

Undergo chest x-ray

DRUG

Cisplatin

Given IV

PROCEDURE

Computed Tomography

Undergo CT

PROCEDURE

Echocardiography Test

Undergo ECHO

OTHER

Electronic Health Record Review

Ancillary studies

OTHER

Fluciclovine F18

Given IV

DRUG

Gemcitabine

Given IV

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

BIOLOGICAL

Nivolumab

Given IV

PROCEDURE

Positron Emission Tomography

Undergo PET

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Ancillary studies

RADIATION

Radiation Therapy

Receive radiation therapy

PROCEDURE

X-Ray Imaging

Undergo dental x-ray

Trial Locations (71)

1145

RECRUITING

Starship Children's Hospital, Grafton

12208

RECRUITING

Albany Medical Center, Albany

15224

RECRUITING

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

17033

RECRUITING

Penn State Children's Hospital, Hershey

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

19803

RECRUITING

Alfred I duPont Hospital for Children, Wilmington

20010

RECRUITING

Children's National Medical Center, Washington D.C.

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

23507

RECRUITING

Children's Hospital of The King's Daughters, Norfolk

27834

RECRUITING

East Carolina University, Greenville

28203

RECRUITING

Carolinas Medical Center/Levine Cancer Institute, Charlotte

29203

RECRUITING

Prisma Health Richland Hospital, Columbia

30329

RECRUITING

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta

32207

RECRUITING

Nemours Children's Clinic-Jacksonville, Jacksonville

32610

RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

32806

RECRUITING

Arnold Palmer Hospital for Children, Orlando

32827

RECRUITING

Nemours Children's Hospital, Orlando

33155

RECRUITING

Nicklaus Children's Hospital, Miami

33607

RECRUITING

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa

35233

RECRUITING

Children's Hospital of Alabama, Birmingham

37203

RECRUITING

The Children's Hospital at TriStar Centennial, Nashville

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

38105

RECRUITING

Saint Jude Children's Research Hospital, Memphis

39216

RECRUITING

University of Mississippi Medical Center, Jackson

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43205

RECRUITING

Nationwide Children's Hospital, Columbus

44106

RECRUITING

Rainbow Babies and Childrens Hospital, Cleveland

45229

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

46202

RECRUITING

Riley Hospital for Children, Indianapolis

49503

RECRUITING

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

60611

RECRUITING

Lurie Children's Hospital-Chicago, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

63110

RECRUITING

Washington University School of Medicine, St Louis

64108

RECRUITING

Children's Mercy Hospitals and Clinics, Kansas City

68114

RECRUITING

Children's Hospital and Medical Center of Omaha, Omaha

68198

RECRUITING

University of Nebraska Medical Center, Omaha

70118

RECRUITING

Children's Hospital New Orleans, New Orleans

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

RECRUITING

Cook Children's Medical Center, Fort Worth

77030

RECRUITING

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

RECRUITING

M D Anderson Cancer Center, Houston

78207

RECRUITING

Children's Hospital of San Antonio, San Antonio

78723

RECRUITING

Dell Children's Medical Center of Central Texas, Austin

80045

RECRUITING

Children's Hospital Colorado, Aurora

85016

RECRUITING

Phoenix Childrens Hospital, Phoenix

90242

RECRUITING

Kaiser Permanente Downey Medical Center, Downey

92123

RECRUITING

Rady Children's Hospital - San Diego, San Diego

92354

RECRUITING

Loma Linda University Medical Center, Loma Linda

93636

RECRUITING

Valley Children's Hospital, Madera

94158

RECRUITING

UCSF Medical Center-Mission Bay, San Francisco

94609

RECRUITING

UCSF Benioff Children's Hospital Oakland, Oakland

94611

RECRUITING

Kaiser Permanente-Oakland, Oakland

98105

RECRUITING

Seattle Children's Hospital, Seattle

98405

RECRUITING

Mary Bridge Children's Hospital and Health Center, Tacoma

72202-3591

RECRUITING

Arkansas Children's Hospital, Little Rock

06106

RECRUITING

Connecticut Children's Medical Center, Hartford

04074

RECRUITING

Maine Children's Cancer Program, Scarborough

07601

RECRUITING

Hackensack University Medical Center, Hackensack

08903

RECRUITING

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick

07112

RECRUITING

Newark Beth Israel Medical Center, Newark

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

T3B 6A8

RECRUITING

Alberta Children's Hospital, Calgary

T6G 2B7

RECRUITING

University of Alberta Hospital, Edmonton

H3H 1P3

RECRUITING

The Montreal Children's Hospital of the MUHC, Montreal

H3T 1C5

RECRUITING

Centre Hospitalier Universitaire Sainte-Justine, Montreal

J1H 5N4

RECRUITING

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH