Efficacy and Safety of Colistimethate Sodium for Injection in The Treatment of Carbapenem-Resistant Enterobacteriaceae Infection

NARecruitingINTERVENTIONAL
Enrollment

404

Participants

Timeline

Start Date

November 27, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Carbapenem-Resistant Enterobacteriaceae Infection
Interventions
DRUG

treatment with or without colistin

For patients in this treatment group, colistin based therapy is used. Colistin combined with metroperan or imipenem(MIC≤8mg/L),or colistin combined with tigecycline, or colistin combined with aminoglycosides (amikacin) are suggested to treat patients diagnosed with hospital-acquired pneumonia or bloodstream infection caused by carbapenem-resistant enterobacteriaceae. For patients in the control, best available treatment without colistin is uesed; Ceftazidime-avibactam, tigecycline combined with metroperan or imipenem(MIC≤8mg/L), tigecycline combined with aminoglycosides (amikacin) are suggested to treat patients diagnosed with hospital-acquired pneumonia or bloodstream infection caused by carbapenem-resistant enterobacteriaceae.

Trial Locations (15)

210000

RECRUITING

Zhongda Hospital Affiliated to Southeast University, Nanjing

214000

RECRUITING

Wuxi No.2 People's Hospital, Wuxi

RECRUITING

Yixing People's Hospital, Yixing

215000

RECRUITING

Suzhou Municipal Hospitial, Suzhou

RECRUITING

The First Affiliated Hospital of Soochow University, Suzhou

221000

RECRUITING

Xuzhou Central Hospital, Xuzhou

222000

RECRUITING

The First Hospital of Lianyungang, Lianyungang

223000

RECRUITING

Huai'an First People's Hospital, Huai'an

224000

RECRUITING

Yancheng No.1 People's Hospital, Yancheng

225000

RECRUITING

Northern Jiangsu People's Hospital, Yangzhou

225300

RECRUITING

JiangsuTaizhou People's Hospital, Taizhou

226000

RECRUITING

Affiliated Hospital of Nantong University, Nantong

230000

RECRUITING

Anhui Provincial People's Hospital, Hefei

RECRUITING

The First Hospital of Anhui Medical University, Hefei

362200

RECRUITING

Jinjiang Municipal Hospitall, Jinjiang

All Listed Sponsors
lead

Southeast University, China

OTHER