Evaluation of the Effect of Novel Recruitment Maneuver Therapy for Postoperative Pulmonary Atelectasis

NACompletedINTERVENTIONAL
Enrollment

77

Participants

Timeline

Start Date

September 10, 2023

Primary Completion Date

April 20, 2024

Study Completion Date

April 20, 2024

Conditions
Postoperative Pulmonary AtelectasisNegative Pressure Therapy
Interventions
DEVICE

Negative extra-abdominal pressure (NEXAP)-based lung recruitment maneuver

The ventilator mode was changed from SIMV to PSV before LRM. After that, the abdominal pressure cardiopulmonary resuscitation (CPR-LW100) instrument was adopted and adsorbed on the epigastrium of patients. The LRM was performed by pulling up (tension of 20-30 kg) and compressing downward (tension\<10 kg) alternately on the abdomen of the patients with a frequency of 12 times per minute to support and maintain breathing. The whole LRM procedure lasted for 3 minutes in total. After LRM, the ventilator mode was changed to its baseline settings.

OTHER

stepwise positive end-expiratory pressure (PEEP)-based lung recruitment maneuver

The ventilator mode was changed from SIMV to PSV before LRM. After that, PEEP was increased gradually (every 3-5cmH2O per 30s) from baseline (5-8 cmH2O) to 20cmH2O. The PEEP level was maintained at 20cmH2O for 60s, followed by decrements to baseline PEEP (every 3-5cmH2O per 30s). After LRM, the ventilator was changed to the baseline settings.

Trial Locations (1)

210000

Nanjing First Hospital, Nanjing

All Listed Sponsors
lead

Jilai Xiao

OTHER

NCT06049173 - Evaluation of the Effect of Novel Recruitment Maneuver Therapy for Postoperative Pulmonary Atelectasis | Biotech Hunter | Biotech Hunter