Oral Care With 3% Hydrogen Peroxide (Oroxid®) in ICU - Effects on the Lower Airway Microbial Colonisation

PHASE4RecruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

May 1, 2024

Primary Completion Date

June 30, 2025

Study Completion Date

December 31, 2025

Conditions
VAP - Ventilator Associated Pneumonia
Interventions
DRUG

Oroxid®

"All patients in experimental arm will receive usual best medical and nursing care with respect to VAP prevention including recently reviewed local ventilator bundle ; standard microbial surveillance (tracheal aspirate) will be performed twice a week (Monday, Thursday) and always ad hoc according to the clinical situation. This reflects current practice. Daily oral care will be provided using Oroxid® mouthwash."

DRUG

Chlorhexidine mouthwash

"All patients in experimental arm will receive usual best medical and nursing care with respect to VAP prevention including recently reviewed local ventilator bundle ; standard microbial surveillance (tracheal aspirate) will be performed twice a week (Monday, Thursday) and always ad hoc according to the clinical situation. This reflects current practice. Daily oral care will be provided using 0,2% chlorhexidine"

Trial Locations (1)

11000

RECRUITING

3rd Faculty of Medicine and FNKV, Prague

All Listed Sponsors
lead

Charles University, Czech Republic

OTHER