ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin)

PHASE3CompletedINTERVENTIONAL
Enrollment

3,214

Participants

Timeline

Start Date

September 5, 2023

Primary Completion Date

June 3, 2024

Study Completion Date

November 4, 2024

Conditions
Covid19
Interventions
OTHER

Placebo

Each study arm will contain a placebo comparator. Placebo will look similar to study drug and will be administered via the same route of administration and dose. However, placebo will be an inactive substance, containing no study drug.

DRUG

Metformin

Metformin IR tablets contain the active metformin hydrochloride and inactive ingredients including povidone and magnesium stearate. Commercially available metformin 500 mg tablets will be provided.

Trial Locations (110)

10065

Weill Cornell Medical College, New York

10701

Spinal Pain and Medical Rehab, PC, Yonkers

13323

Geriatrics and Medical Associates, Clinton

15213

University of Pittsburgh, Pittsburgh

19067

Bucks County Clinical Research, Morrisville

19140

Temple University Hospital, Philadelphia

20037

George Washington University Hospital, Washington D.C.

20855

Jadestone Clinical Research, LLC, Rockville

22903

University of Virginia, Charlottesville

27151

Wake Forest Baptist Health, Winston-Salem

27520

Vaidya MD PLLC, Clayton

27577

Superior Clinical Research, Smithfield

27701

Duke Clinical Research Institute, Durham

27710

Duke University Medical Center, Durham

28117

Lapis Clinical Research, Mooresville

28334

Maria Medical Center, PLLC, Dunn

29403

Medical University of South Carolina, Charleston

30052

Christ the King Health Care, P.C., Loganville

30094

HOPE Clinical Research and Wellness, Conyers

30134

Elite Family Practice, Douglasville

30310

Morehouse School of Medicine, Atlanta

30322

Emory Healthcare, Atlanta

30349

Essential Medical Care, Inc., College Park

31015

David Kavtaradze MD, Inc., Cordele

31201

Miller Family Practice, LLC, Macon

31904

Clincept, LLC, Columbus

32159

UF Health Precision Health Research, The Villages

32209

University of Florida-JAX-ASCENT, Jacksonville

32244

AMRON Vitality and Wellness Center, LLC, Jacksonville

32308

Tallahassee Memorial Hospital, Tallahassee

32606

Lupus Foundation of Gainesville, Gainesville

32611

University of Florida Health, Gainesville

32746

Sunshine Walk In Clinic, Lake Mary

33012

L and A Morales Healthcare, Inc, Hialeah

33016

The Angel Medical Research Corporation, Miami Lakes

33136

Jackson Memorial Hospital, Miami

University of Miami, Miami

33157

Innovation Clinical Trials Inc., Palmetto Bay

33173

Well Pharma Medical Research, Miami

33313

Lice Source Services Plantation, Plantation

33441

Arena Medical Group, Deerfield Beach

33606

Tampa General Hospital, Tampa

33707

Premier Health, St. Petersburg

33805

Lakeland Regional Medical Center, Lakeland

37067

Clinical Trials Center of Middle TN, Franklin

37075

Rapha Family Wellness, Hendersonville

37203

Vanderbilt University Medical Center, Nashville

37938

Medical Specialists of Knoxville, Knoxville

42330

A New Start II, LLC, Central City

44718

Diabetes and Endocrinology Assoc. of Stark County, Canton

45242

TriHealth, Inc, Montgomery

45267

University of Cincinnati, Cincinnati

46360

Franciscan Health Michigan City, Michigan City

46545

Del Pilar Medical and Urgent Care, Mishawaka

48124

Ananda Medical Clinic, Dearborn

48202

GFC of Southeastern Michigan, PC, Detroit

48206

Romancare Health Services, Detroit

55455

University of Minnesota, Minneapolis

55805

Essentia Health, Duluth

60047

Advanced Medical Care, Ltd, Lake Zurich

60153

Loyola University Medical Center, Maywood

60201

NorthShore Medical Group, Evanston

60611

Northwestern Univesity, Chicago

60612

Rush University Medical Center, Chicago

60618

Olivo Wellness Medical Center, Chicago

65212

University of Missouri - Columbia, Columbia

67214

University of Kansas - Wichita, Wichita

70112

University Medical Center- New Orleans, New Orleans

70121

Ochsner Clinic Foundation, New Orleans

71301

Christus Saint Frances Hospita, Alexandria

72205

University of Arkansas Medical Sciences, Little Rock

74104

Ascension St. John, Tulsa

74701

The Heart and Medical Center, Durant

74743

Hugo Medical clinic, Hugo

75013

Express Family Clinic, Allen

75039

Texas Health Physicians Group, Irving

76107

Texas Health Physicians Group, Fort Worth

77030

University of Texas Health Science Center at Houston, Houston

77338

Family Practice Doctors P.A., Humble

77339

Kintex Group Texas LLC, DBA Activian Clinical Research, Kingwood

77479

Jeremy W. Szeto, D.O., P.A., Sugar Land

77504

University Diagnostics and Treatment Clinic, Pasadena

77562

Highlands Medical Associates, P.A., Highlands

78229

University of Texas Health Science Center at San Antonio, San Antonio

78234

Brooke Army Medical Center, Fort Sam Houston

78539

DHR Health Institute for Research, Edinburg

78596

University of Texas Rio Grande Valley, Weslaco

79905

Texas Tech University Health Sciences Center, El Paso

80917

Doctors Medical Group of Colorado Springs, P.C., Colorado Springs

80924

Pine Ridge Family Medicine Inc., Colorado Springs

85203

First Care Medical Clinic, Mesa

85224

Chandler Regional Medical Center, Chandler

85298

Lamb Health, LLC, Gilbert

85382

Trident Health Center, Peoria

87505

Christus St. Vincent Regional Medical Center, Santa Fe

89052

Comprehensive Pain Management and Endocrinology, Henderson

91342

Olive View - UCLA Medical Center, Sylmar

91606

Assuta Family Medical Group APMC, North Hollywood

92663

Hoag Memorial Hospital Presbyterian, Newport Beach

94304

Stanford, Palo Alto

99204

Providence Medical Research Center, Spokane

06905

Tabitha B. Fortt, M.D., LLC, Stamford

21287-1900

Johns Hopkins Hospital, Baltimore

02118

Boston Medical Center, Boston

01843

Health Quality Primary Care, Lawrence

01655

University of Massachusetts Medical School, Worcester

07002

Focus Clinical Research Solutions, Bayonne

07747

Raritan Bay Primary Care & Cardiology Associates, Matawan

07514

G&S Medical Associates, LLC, Paterson

08012

Mediversity Healthcare, Turnersville

All Listed Sponsors
collaborator

National Center for Advancing Translational Sciences (NCATS)

NIH

collaborator

Vanderbilt University Medical Center

OTHER

lead

Susanna Naggie, MD

OTHER

NCT06042855 - ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin) | Biotech Hunter | Biotech Hunter