Flurbiprofen Versus Aloe Vera Gel in the Treatment of Chronic Periodontitis in Smoking Patients.

PHASE4CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

September 30, 2022

Primary Completion Date

May 25, 2023

Study Completion Date

July 19, 2023

Conditions
Periodontitis Chronic Generalized Severe
Interventions
DRUG

2.5% flurbiprofen

Gel was made of 20% poloxamer and 10% ethanol as an Optimum formulation with sustained release up to 48 hours and a reasonable sol gel transition phase (adjunctive to SRP)

DRUG

98% aloe vera

the Aloe vera gel employed possessed a concentration of 98% and was obtained from the reputable brand Avivir (Denmark). The remaining 2% comprised normal saline. The process of obtaining the 98% Aloe vera gel involved meticulous washing of mature Aloe Vera leaves under running water, followed by the removal of their outer skin. Subsequently, each leaf was divided into smaller pieces, from which the gel was allowed to seep out and carefully collected in a sterile container. The collected gel was then stored at 4°C until the time of its application in the study (adjunctive to SRP)

OTHER

Placebo

saline

Trial Locations (1)

Unknown

Beirut Arab University, Beirut

All Listed Sponsors
lead

Beirut Arab University

OTHER