Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,454

Participants

Timeline

Start Date

September 22, 2023

Primary Completion Date

March 2, 2026

Study Completion Date

May 22, 2026

Conditions
Chronic Obstructive Pulmonary Disease (COPD)
Interventions
DRUG

Placebo

Placebo administered subcutaneously, equivalent volume to tozorakimab throughout the study.

DRUG

Tozorakimab

Administered subcutaneously tozorakimab and placebo throughout the study.

Trial Locations (385)

161

Research Site, Roma

1070

Research Site, Brussels

1203

Research Site, Budapest

1330

Research Site, Adana

1756

Research Site, Sofia

1888

Research Site, San Juan Bautista

2100

Research Site, Gödöllő

2400

Research Site, København NV

2440

Research Site, Százhalombatta

2600

Research Site, Dupnitsa

2650

Research Site, Edegem

Research Site, Hvidovre

2800

Research Site, Mechelen

3000

Research Site, Leuven

3780

Research Site, Edelény

3860

Research Site, Encs

4000

Research Site, San Miguel de Tucumán

Research Site, Roskilde

4003

Research Site, Plovdiv

4032

Research Site, Debrecen

4080

Research Site, Hajdúnánás

4500

Research Site, Panagyurishte

4700

Research Site, Næstved

5000

Research Site, Veliko Tanovo

Research Site, Szolnok

5101

Research Site, Namur

5460

Research Site, Alor Star

6300

Research Site, Haskovo

7100

Research Site, Vejle

7600

Research Site, Mar del Plata

7635

Research Site, Pécs

8200

Research Site, Aarhus

8500

Research Site, Kortrijk

8600

Research Site, Yambol

8800

Research Site, Roeselare

9000

Research Site, Ghent

Research Site, Aalborg

9200

Research Site, Mosonmagyaróvár

10000

Research Site, Hanoi

10003

Research Site, Cáceres

10119

Research Site, Berlin

10451

Research Site, The Bronx

10717

Research Site, Berlin

10787

Research Site, Berlin

10961

Research Site, Berlin

11521

Research Site, Athens

12120

Research Site, Khlong Luang

12157

Research Site, Berlin

12159

Research Site, Berlin

12203

Research Site, Berlin

13015

Research Site, Marseille

13100

Research Site, Aix-en-Provence

13187

Research Site, Berlin

14068

Research Site, Anyang-si

15046

Research Site, Lima

15102

Research Site, Lima

15586

Research Site, Kota Bharu

17562

Research Site, Athens

20000

Research Site, Mueang

20001

Research Site, Piura

20037

Research Site, Washington D.C.

21001

Research Site, Vinnytsia

21029

Research Site, Vinnytsia

21286

Research Site, Towson

22000

Research Site, Muang

22927

Research Site, Großhansdorf

25100

Research Site, Kuantan

26426

Research Site, Wŏnju

27100

Research Site, Pavia

27103

Research Site, Winston-Salem

27834

Research Site, Greenville

28078

Research Site, Huntersville

28273

Research Site, Charlotte

28850

Research Site, Madrid

29000

Research Site, Quimper

29010

Research Site, Málaga

29340

Research Site, Gaffney

29379

Research Site, Union

29609

Research Site, Brest

30000

Research Site, Nakhon Ratchasima

30038

Research Site, Lithonia

30159

Research Site, Hanover

30344

Research Site, Atlanta

31224

Research Site, Peine

32174

Research Site, Ormond Beach

33343

Research Site, Mersin

33435

Research Site, Boynton Beach

33805

Research Site, Lakeland

33813

Research Site, Lakeland

33990

Research Site, Cape Coral

34102

Research Site, Naples

34295

Research Site, Montpellier

34470

Research Site, Ocala

34722

Research Site, Istanbul

35037

Research Site, Marburg

35128

Research Site, Padua

35205

Research Site, Birmingham

35603

Research Site, Decatur

35660

Research Site, Sheffield

37404

Research Site, Chattanooga

37643

Research Site, Elizabethton

38305

Research Site, Jackson

38700

Research Site, La Tronche

39008

Research Site, Santander

40002

Research Site, Muang

40503

Research Site, Lexington

41124

Research Site, Modena

42101

Research Site, Bowling Green

42415

Research Site, Daegu

42699

Research Site, Solingen

43000

Research Site, Kajang

44124

Research Site, Cona

45127

Research Site, Essen

45439

Research Site, Dayton

45634

Research Site, Tarasove Village

45801

Research Site, Lima

46001

Research Site, Ternopil

47441

Research Site, Moers

48202

Research Site, Detroit

50009

Research Site, Zaragoza

50051

Research Site, Shijiazhuang

51069

Research Site, Cologne

51092

Research Site, Reims

53142

Research Site, Kenosha

54907

Research Site, Jeonju

55425

Research Site, Minneapolis

56100

Research Site, Pisa

57010

Research Site, Thessaloniki

58022

Research Site, Chernivtsi

59100

Research Site, Kuala Lumpur

60389

Research Site, Frankfurt am Main

60596

Research Site, Frankfurt

60607

Research Site, Chicago

60616

Research Site, Chicago

61820

Research Site, Champaign

63005

Research Site, Chesterfield

63017

Research Site, Chesterfield

63401

Research Site, Hannibal

64283

Research Site, Darmstadt

67002

Research Site, Andover

68024

Research Site, Colmar

68046

Research Site, Papillion

69317

Research Site, Lyon

69655

Research Site, Villefranche-sur-Saône

70000

Research Site, Ho Chi Minh City

Research Site, Hochiminh

70300

Research Site, Seremban

71100

Research Site, Foggia

71409

Research Site, Heraklion

74370

Research Site, Epagny Metz-Tessy

75069

Research Site, McKinney

75254

Research Site, Dallas

76019

Research Site, Ivano-Frankivsk

77008

Research Site, Houston

78258

Research Site, San Antonio

79902

Research Site, El Paso

80014

Research Site, Aurora

80131

Research Site, Napoli

80301

Research Site, Boulder

80335

Research Site, München

81241

Research Site, München-Pasing

84067

Research Site, Roy

85027

Research Site, Phoenix

85365

Research Site, Yuma

85704

Research Site, Tucson

86150

Research Site, Augsburg

88018

Research Site, Uzhhorod

89102

Research Site, Las Vegas

90027

Research Site, Los Angeles

90110

Research Site, Hat Yai

90419

Research Site, Nuremberg

92663

Research Site, Newport Beach

92683

Research Site, Westminster

94109

Research Site, San Francisco

97527

Research Site, Grants Pass

100000

Research Site, Hanoi

Research Site, Hà Nội

100002

Research Site, Zhytomyr

100029

Research Site, Beijing

110004

Research Site, Shenyang

110016

Research Site, Shenyang

110029

Research Site, Delhi

110075

Research Site, Dwārka

130021

Research Site, Changchun

200040

Research Site, Shanghai

200240

Research Site, Shanghai

200433

Research Site, Shanghai

201199

Research Site, Shanghai

210006

Research Site, Nanjing

210009

Research Site, Nanjing

221000

Research Site, Xuzhou

221009

Research Site, Xuzhou

230061

Research Site, Hefei

248001

Research Site, Dehradun

250001

Research Site, Jinan

252000

Research Site, Liaocheng

266000

Research Site, Qingdao

302012

Research Site, Jaipur

302039

Research Site, Jaipur

305001

Research Site, Ajmer

315010

Research Site, Ningbo

317000

Research Site, Linhai

318000

Research Site, Taizhou

330006

Research Site, Nanchang

337055

Research Site, Pingxiang

400037

Research Site, Chongqing

400042

Research Site, Chongqing

410015

Research Site, Changsha

430022

Research Site, Wuhan

430030

Research Site, Wuhan

430033

Research Site, Changsha

440012

Research Site, Nagpur

500035

Research Site, Hyderabad

500038

Research Site, Hyderabad

510145

Research Site, Guangzhou

510163

Research Site, Guangzhou

510515

Research Site, Guangzhou

516002

Research Site, Huizhou

518020

Research Site, Shenzhen

530017

Research Site, Visakhapatnam

530021

Research Site, Nanning

610014

Research Site, Chengdu

610072

Research Site, Chengdu

611130

Research Site, Chengdu

637000

Research Site, Nanchong

643000

Research Site, Zigong

700000

Research Site, Ho Chi Minh City

700053

Research Site, Kolkata

710006

Research Site, Xi'an

730030

Research Site, Lanzhou

750004

Research Site, Yinchuan

750306

Research Site, Hohhot

2260000

Research Site, Quillota

2540488

Research Site, Viña del Mar

4030000

Research Site, Concepción

7500010

Research Site, Santiago

7501126

Research Site, Santiago

7750495

Research Site, Santiago

7770484

Research Site, Chile

8380453

Research Site, Santiago

90035074

Research Site, Porto Alegre

08755

Research Site, Toms River

C1121 ABE

Research Site, Buenos Aires

C1414AIF

Research Site, Buenos Aires

C1025ABI

Research Site, CABA

C1425BEN

Research Site, CABA

X5003DCE

Research Site, Córdoba

B1904

Research Site, La Plata

B7600GWV

Research Site, Mar del Plata

M5500CCG

Research Site, Mendoza

B1878FNR

Research Site, Quilmes

B1646EBJ

Research Site, San Fernando

14784-400

Research Site, Barretos

30150-221

Research Site, Belo Horizonte

89030-101

Research Site, Blumenau

83.430-000

Research Site, Campina Grande do Sul

13060-080

Research Site, Campinas

60430-270

Research Site, Fortaleza

90610-000

Research Site, Porto Alegre

91010-006

Research Site, Porto Alegre

09715090

Research Site, São Bernardo do Campo

15090-000

Research Site, São José do Rio Preto

05403-000

Research Site, São Paulo

13271-130

Research Site, Valinhos

T3R 1W7

Research Site, Calgary

V1Y 4N7

Research Site, Kelowna

L1S 2J5

Research Site, Ajax

L7N 3V2

Research Site, Burlington

M5T 3A9

Research Site, Toronto

K0C 2K0

Research Site, Winchester

G6V 0C9

Research Site, Lévis

G1V 4G5

Research Site, Québec

J6E 2B4

Research Site, Saint-Charles-Borromée

050051

Research Site, Shijiazhuang

06108

Research Site, Halle

06120

Research Site, Halle

04299

Research Site, Leipzig

673 008

Research Site, Calicut

520 008

Research Site, Vijayawada

T12 DV56

Research Site, Cork

D24 NR0A

Research Site, Dublin

H91 YR71

Research Site, Galway

A92 VW28

Research Site, Moneymore

030-8553

Research Site, Aomori

070-8644

Research Site, Asahikawa-shi

818-8502

Research Site, Chikushino-shi

104-0031

Research Site, Chūōku

426-8677

Research Site, Fujieda-shi

814-0180

Research Site, Fukuoka

901-2214

Research Site, Ginowan-shi

583-8588

Research Site, Habikino-shi

041-8680

Research Site, Hakodate-shi

430-8525

Research Site, Hamamatsu

820-8505

Research Site, Iizuka-shi

173-8610

Research Site, Itabashi-ku

594-0073

Research Site, Izumi-shi

892-0847

Research Site, Kagoshima

816-0813

Research Site, Kasuga-shi

486-8510

Research Site, Kasugai-shi

586-8521

Research Site, Kawachinagano-shi

802-0001

Research Site, Kitakyushu-shi

204-8522

Research Site, Kiyose-shi

650-0047

Research Site, Kobe

862-0954

Research Site, Kumamoto

525-8585

Research Site, Kusatsu-shi

612-8555

Research Site, Kyoto

515-8544

Research Site, Matsusaka-shi

562-0003

Research Site, Minoh

505-8510

Research Site, Minokamo Shi

509-6134

Research Site, Mizunami-shi

020-0066

Research Site, Morioka

457-8511

Research Site, Nagoya

783-8505

Research Site, Nankoku-shi

783-8509

Research Site, Nankoku-shi

503-8502

Research Site, Ogaki-shi

904-2143

Research Site, Okinawa-shi

837-0911

Research Site, Omuta-shi

543-8555

Research Site, Osaka

252-0143

Research Site, Sagamihara-shi

252-0315

Research Site, Sagamihara-shi

762-8550

Research Site, Sakaide-shi

591-8555

Research Site, Sakaishi

001-0901

Research Site, Sapporo

006-8555

Research Site, Sapporo

063-0005

Research Site, Sapporo

064-0804

Research Site, Sapporo

981-0911

Research Site, Sendai

420-8630

Research Site, Shizuoka

190-8531

Research Site, Tachikawa-shi

791-0281

Research Site, Toon-shi

302-0022

Research Site, Toride-shi

171-0014

Research Site, Toshima-ku

560-8552

Research Site, Toyonaka-shi

755-8505

Research Site, Ube

386-8610

Research Site, Ueda-shi

901-2132

Research Site, Urasoe-shi

832-0059

Research Site, Yanagawa-shi

221-0855

Research Site, Yokohama

232-0024

Research Site, Yokohama

232-0066

Research Site, Yokohama

236-0037

Research Site, Yokohama

03310

Research Site, Mexico City

5223 GZ

Research Site, 's-Hertogenbosch

6815 AD

Research Site, Arnhem

4818 CK

Research Site, Breda

6419 PC

Research Site, Heerlen

6043 CV

Research Site, Roermond

3045 PM

Research Site, Rotterdam

3083 AN

Research Site, Rotterdam

7207 AE

Research Site, Zutphen

LIMA 21

Research Site, Lima

LIMA 14

Research Site, Santa Beatriz

15-044

Research Site, Bialystok

85-796

Research Site, Bydgoszcz

32-500

Research Site, Chrzanów

05-825

Research Site, Grodzisk Mazowiecki

25-426

Research Site, Kielce

30-033

Research Site, Krakow

31-513

Research Site, Krakow

09-407

Research Site, Płock

35-205

Research Site, Rzeszów

405-760

Research Site, Incheon

04763

Research Site, Seoul

05030

Research Site, Seoul

06351

Research Site, Seoul

06591

Research Site, Seoul

06973

Research Site, Seoul

08916

Research Site, Badalona(Barcelona)

08035

Research Site, Barcelona

06800

Research Site, Mérida

02002

Research Site, Kyiv

02081

Research Site, Kyiv

03037

Research Site, Kyiv

03680

Research Site, Kyiv

BD9 6RJ

Research Site, Bradford

HU16 5JQ

Research Site, Cottingham

G4 0SF

Research Site, Glasgow

LS9 7TF

Research Site, Leeds

L7 8XP

Research Site, Liverpool

EC1M 6BQ

Research Site, London

NW3 2QG

Research Site, London

SK10 3BL

Research Site, Macclesfield

NE7 7AF

Research Site, Newcastle upon Tyne

PO6 3LY

Research Site, Portsmouth

WF1 4DG

Research Site, Wakefield

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY