4,532
Participants
Start Date
September 12, 2023
Primary Completion Date
September 30, 2025
Study Completion Date
October 31, 2028
Dexmedetomidine
A loading dose of dexmedetomidine (0.6 μg/kg) will be administered over 10-15 minutes before anaesthesia induction, followed by a continuous infusion at a rate of 0.5 μg/kg/hr till 1 hour before the end of surgery. Patient-controlled dexmedetomidine supplemented sufentanil analgesia will be provided after surgery: the formula contains a mixture of sufentanil (1.25 μg/ml) and dexmedetomidine (1.25 μg/ml), diluted with normal saline to a total volume of 160 ml; the analgesic pump is set to administer a background infusion at a rate of 1 ml/h, with patient-controlled bolus of 2 ml each time and a lockout time of 8 minutes.
Placebo
Volume-matched normal saline will be administered in the same rate and volume for the same duration as in the dexmedetomidine group during anesthesia. Patient-controlled sufentanil analgesia will be provided after surgery: the formula contains sufentanil (1.25 μg/ml), diluted with normal saline to a total volume of 160 ml; the analgesic pump is set to administer a background infusion at a rate of 1 ml/h, with patient-controlled bolus of 2 ml each time and a lockout time of 8 minutes.
RECRUITING
Peking University First Hospital, Beijing
RECRUITING
Tsinghua University Yuquan Hospital, Beijing
RECRUITING
Bethune First Hospital Of Jilin University, Changchun
RECRUITING
The Second Affiliated Hospital of Harbin Medical University, Harbin
RECRUITING
Harbin Medical University Cancer Hospital, Harbin
RECRUITING
Cancer Hospital Chinese Academy of Medical Sciences, Beijing
RECRUITING
Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai
RECRUITING
Nanjing General Hospital of Nanjing Military Region, Nanjing
NOT_YET_RECRUITING
General hospital of eastern theater command, Nanjing
RECRUITING
Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing
RECRUITING
The Second Affiliated Hospital of Suzhou University, Suzhou
RECRUITING
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei
RECRUITING
Shandong Provincial Hospital Heze Hospital, Heze
NOT_YET_RECRUITING
Zhejiang Cancer Hospital, Zhejiang
RECRUITING
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou
RECRUITING
Fujian Provincial Hospital, Fuzhou
RECRUITING
The First Affiliated Hospital of Fujian Medical University, Fuzhou
RECRUITING
Jinjiang City Hospital (Shanghai Sixth People's Hospital, Fujian Hospital), Jinjiang
RECRUITING
The First Affiliated Hospital of Army Medical University (Southwest Hospital), Chongqing
RECRUITING
Xiangya Hospital Central South university, Changsha
NOT_YET_RECRUITING
The First Affiliated Hospital of University of South China, Hengyang
RECRUITING
The First Affiliated Hospital of Zhengzhou University, Zhengzhou
RECRUITING
Henan Provincial People's Hospital, Zhengzhou
RECRUITING
Guangdong General Hospital, Guangzhou
RECRUITING
Peking University Shenzhen Hospital, Shenzhen
RECRUITING
The First Affiliated Hospital of Shenzhen University, Shenzhen
RECRUITING
The Second Affiliated Hospital of Guangxi Medical University, Nanning
RECRUITING
Affiliated Cancer Hospital of Guangxi Medical University, Nanning
RECRUITING
Xijing Hospital, Fourth Military Medical University, Xi'an
NOT_YET_RECRUITING
General Hospital of Ningxia Medical University, Yinchuan
RECRUITING
People's Hospital of Ningxia Hui Autonomous Region, Yinchuan
RECRUITING
First Affiliated Hospital of Xinjiang Medical University, Ürümqi
RECRUITING
The First Affiliated Hospital of China University of Science and Technology, Hefei
NOT_YET_RECRUITING
Fujian Medical University Union Hospital, Fuzhou
RECRUITING
The Fourth Hospital of Hebei Medical University, Shijiazhuang
NOT_YET_RECRUITING
Tangshan Workers' Hospital, Tangshan
RECRUITING
Shanxi Cancer Hospital, Taiyuan
RECRUITING
Shanxi Provincial People's Hospital, Taiyuan
RECRUITING
Shanxi Bethune Hospital, Taiyuan
Peking University
OTHER
Peking University First Hospital
OTHER