338
Participants
Start Date
July 1, 2024
Primary Completion Date
July 29, 2030
Study Completion Date
October 29, 2030
Autologous Hematopoietic Stem Cell Transplantation
Given IV
Biopsy
Undergo fat pad biopsy
Biospecimen Collection
Undergo blood and urine specimen collection
Bone Marrow Aspiration
Undergo bone marrow aspiration
Bone Marrow Biopsy
Undergo bone marrow biopsy
Bortezomib
Given SC
Computed Tomography
Undergo CT scan
Cyclophosphamide
Given PO or IV
Daratumumab and Hyaluronidase-fihj
Given SC
Dexamethasone
Given PO or IV
Echocardiography
Undergo echocardiography
Magnetic Resonance Imaging
Undergo MRI
Melphalan
Given IV
Positron Emission Tomography
Undergo PET-CT
Stem Cell Isolation
Undergo stem cell collection
Survey Administration
Ancillary study
RECRUITING
Geisinger Medical Center, Danville
RECRUITING
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre
RECRUITING
Thomas Jefferson University Hospital, Philadelphia
RECRUITING
Wayne State University/Karmanos Cancer Institute, Detroit
RECRUITING
Weisberg Cancer Treatment Center, Farmington Hills
RECRUITING
Mission Cancer and Blood - Ankeny, Ankeny
RECRUITING
Iowa Methodist Medical Center, Des Moines
RECRUITING
Mission Cancer and Blood - Des Moines, Des Moines
RECRUITING
Medical College of Wisconsin, Milwaukee
RECRUITING
Gundersen Lutheran Medical Center, La Crosse
RECRUITING
Loyola University Medical Center, Maywood
RECRUITING
Carle Cancer Center, Urbana
RECRUITING
Carle at The Riverfront, Danville
RECRUITING
Carle Physician Group-Mattoon/Charleston, Mattoon
RECRUITING
Carle Physician Group-Effingham, Effingham
RECRUITING
Washington University School of Medicine, St Louis
RECRUITING
Siteman Cancer Center-South County, St Louis
RECRUITING
Siteman Cancer Center at Christian Hospital, St Louis
RECRUITING
Siteman Cancer Center at West County Hospital, Creve Coeur
RECRUITING
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
RECRUITING
University of Kansas Cancer Center, Kansas City
RECRUITING
University of Kansas Hospital-Westwood Cancer Center, Westwood
RECRUITING
Nebraska Medicine-Village Pointe, Omaha
RECRUITING
Nebraska Medicine-Bellevue, Bellevue
RECRUITING
University of Nebraska Medical Center, Omaha
RECRUITING
Providence Portland Medical Center, Portland
RECRUITING
Providence Saint Vincent Medical Center, Portland
RECRUITING
Oregon Health and Science University, Portland
RECRUITING
Smilow Cancer Hospital-Derby Care Center, Derby
RECRUITING
Smilow Cancer Hospital Care Center - Guilford, Guilford
RECRUITING
Smilow Cancer Hospital Care Center at Saint Francis, Hartford
RECRUITING
Yale University, New Haven
RECRUITING
Yale-New Haven Hospital North Haven Medical Center, North Haven
RECRUITING
Walter Reed National Military Medical Center, Bethesda
RECRUITING
Boston Medical Center, Boston
National Cancer Institute (NCI)
NIH
SWOG Cancer Research Network
NETWORK