57
Participants
Start Date
January 10, 2023
Primary Completion Date
January 9, 2026
Study Completion Date
January 9, 2028
Nivolumab
Nivolumab during induction chemotherapy in all groups and during radiochemotherapy in patients with SD or PD after induction or metastases
Cisplatin
Cisplatin during induction chemotherapy and during radiochemotherapy in all groups
5-Fluorouracil
5-Fluoruracil during induction chemotherapy in all groups except of adults \> 25 years with metastatic disease at diagnosis
Gemcitabine
Gemcitabine during induction chemotherapy in patients \> 25 years with metastatic disease at diagnosis
Radiotherapy
After induction therapy in all patients
Interferon beta-1a
In patients \< 26 years after end of radiochemotherapy for 6 months
MRI
At diagnosis and 17 to 22 days after the beginning of cycle 3 of induction therapy
PET
At diagnosis and 17 to 22 days after the beginning of cycle 3 of induction therapy, either as PET-CT or PET-MRI
Patient-Reported Outcomes
For all patients at baseline, before radiochemotherapy, at day 100, and 2 years after enrolment
ACTIVE_NOT_RECRUITING
Department of Pediatric Oncology and Hematology, Charité University Medicine Berlin, Berlin
NOT_YET_RECRUITING
Department of Pediatric Hematology/Oncology, University Medicine Greifswald, Greifswald
RECRUITING
Department of Otorhinolaryngology, University Medical Center Hamburg-Eppendorf,, Hamburg
RECRUITING
Department of Pediatric Oncology, University Hospital Kiel, Kiel
ACTIVE_NOT_RECRUITING
Evangelisches Klinikum Bethel, Children's Hospital, Bielefeld
ACTIVE_NOT_RECRUITING
Department of Pediatric Oncology, Justus-Liebig University of Giessen, Giessen
NOT_YET_RECRUITING
Department of Pediatric Oncology, University Hospital, Göttingen
NOT_YET_RECRUITING
Department of Pediatrics, University Hospital Mageburg, Magdeburg
ACTIVE_NOT_RECRUITING
Clinic for Children and Adolescent Medicine, Klinikum Dortmund, Dortmund
ACTIVE_NOT_RECRUITING
Department of Internal Medicine, Klinikum Dortmund, Dortmund
NOT_YET_RECRUITING
Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen
NOT_YET_RECRUITING
Department of Pediatric Hematology and Oncology, University Hospital Essen, Essen
ACTIVE_NOT_RECRUITING
Department of Pediatric Hematology and Oncology, University Children's Hospital, Münster
RECRUITING
Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne
RECRUITING
Uniklinik RWTH Aachen, Department of Internal Medicine, Aachen
ACTIVE_NOT_RECRUITING
Uniklinik RWTH Aachen, Division of Pediatric Hematology, Oncology, Stem Cell Transplantation, Aachen
NOT_YET_RECRUITING
Department of Pediatric Hematology and Oncology, University Hospital, Bonn
ACTIVE_NOT_RECRUITING
Pediatric Hematology/Oncology, University Medicine Mainz, Mainz
NOT_YET_RECRUITING
Department of Pediatrics, University Hospital, Frankfurt
RECRUITING
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim,, Mannheim
RECRUITING
Universitätsklinikum Tübingen, Klinik für Pädiatrie I, Tübingen
NOT_YET_RECRUITING
Department of Pediatric Hematology/Oncology, University Hospital Freiburg, Freiburg im Breisgau
RECRUITING
Department fo Radiotherapy, University Hospital, Erlangen
ACTIVE_NOT_RECRUITING
Department of Pediatrics, University Hospital Erlangen, Erlangen
NOT_YET_RECRUITING
Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital, Regensburg
ACTIVE_NOT_RECRUITING
Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Children's Hospital, University of Würzburg, Würzburg
RECRUITING
Children's Hospital, Carl-Thiem Klinikum Cottbus, Cottbus
ACTIVE_NOT_RECRUITING
Department of Pediatrics, University Hospital, Technische Universität Dresden, Dresden
RECRUITING
Universitätsklinikum Halle, Klinik für Pädiatrie I, Halle
RECRUITING
Department of Pediatric Oncology, University Children's Hospital, Hamburg
ACTIVE_NOT_RECRUITING
Department of Otorhinolaryngology, Jena University Hospital, Jena
Deutsche Krebshilfe e.V., Bonn (Germany)
OTHER
German Society for Pediatric Oncology and Hematology GPOH gGmbH
OTHER