Clinical Study on the Treatment of Malignant Brain Glioma by QH104 Cell Injection

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

June 1, 2023

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
Brain GliomasHigh-Grade GliomasGBM
Interventions
BIOLOGICAL

Allogenic B7-H3 CAR-γδT cell(QH104)

"Dose escalation (3+3) : dose 1 (1 × 10\^7 CAR+cells) , dose 2 (3 × 10\^7 CAR+cells), dose 3 (6× 10\^7 CAR+cells), once every 4 weeks via an Ommaya reservoir or intrathecal administration.~Dose expansion 1: dose of RP2D, once every 4 weeks via an Ommaya reservoir or intrathecal administration.~Dose expansion 2: 3 × 10\^7 CAR+cells, every two weeks for three consecutive months, then changed to once every 4 weeks via an Ommaya reservoir or intrathecal administration."

Trial Locations (1)

215125

RECRUITING

Dushu Lake Hospital Affiliated to Soochow University, Suzhou

All Listed Sponsors
lead

Dushu Lake Hospital Affiliated to Soochow University

OTHER