NCT06014827View on ClinicalTrials.gov

Biologically Guided Radiation Therapy (BgRT) and Stereotactic Body Radiation Therapy (SBRT) to Tyrosine Kinase Inhibitor in Oligoprogressive Oncogenic Positive Non-Small Cell Lung Carcinoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

October 9, 2024

Primary Completion Date

July 11, 2026

Study Completion Date

July 11, 2026

Conditions
Lung Non-Small Cell CarcinomaStage IV Lung Cancer AJCC v8
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT or PET/CT scan

DRUG

Osimertinib

Given PO

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

RADIATION

Stereotactic Body Radiation Therapy

Undergo BgRT/SBRT

OTHER

Survey Administration

Ancillary study

Trial Locations (2)

91010

RECRUITING

City of Hope Medical Center, Duarte

06520

NOT_YET_RECRUITING

Yale University, New Haven

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER