A Clinical Study of TQB2618 Injection Monotherapy and Combination Regimen (With Penpulimab Injection ±Anlotinib Hydrochloride Capsules) in the Four or Later Lines of Treatment of Advanced Colorectal Cancer.

PHASE1UnknownINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

January 13, 2024

Primary Completion Date

March 31, 2025

Study Completion Date

July 31, 2025

Conditions
Colorectal Cancer
Interventions
DRUG

TQB2618 injection

TQB2618 is a monoclonal antibody targeting T cell immunoglobulin and mucin domain-3 (TIM-3) receptor.

DRUG

Penpulimab injection

Penpulimab is a humanized Immunoglobulin G-1 (IgG1) monoclonal antibody that binds to human programmed cell death 1 (PD-1), a cell membrane protein that is primarily expressed on activated T cells and inhibits T cell activation.

DRUG

Anlotinib hydrochloride capsules

Anlotinib hydrochloride is a muti-target tyrosine kinase inhibitor.

Trial Locations (15)

110002

NOT_YET_RECRUITING

The First Hospital of China Medical University, Shenyang

130021

RECRUITING

Jilin Cancer Hospital, Changchun

232007

NOT_YET_RECRUITING

Huai Nan First People's Hospital, Huainan

236010

RECRUITING

Fuyang Cancer Hospital, Fuyang

272007

NOT_YET_RECRUITING

Affiliated Hospital of Jining Medical University, Jining

350001

RECRUITING

Fujian Cancer Hospital, Fuzhou

361003

NOT_YET_RECRUITING

The First Affiliated Hospital of Xiamen University, Xiamen

410000

NOT_YET_RECRUITING

Hunan Cancer Hospital, Changsha

514031

NOT_YET_RECRUITING

Meizhou People's Hospital (Huangtang Hospital), Meizhou

530021

RECRUITING

Guangxi Medical University Cancer Hospital, Nanning

614003

NOT_YET_RECRUITING

The people's hospital of Leshan, Leshan

621009

NOT_YET_RECRUITING

Mianyang central hospital, Mianyang

710000

NOT_YET_RECRUITING

The First Affiliated Hospital of Air Force Medical University, Xi'an

NOT_YET_RECRUITING

The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an

030013

NOT_YET_RECRUITING

Shanxi Cancer Hospital, Taiyuan

All Listed Sponsors
lead

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

INDUSTRY