280
Participants
Start Date
April 4, 2024
Primary Completion Date
August 17, 2027
Study Completion Date
March 20, 2031
Durvalumab
Participants will receive intravenous (IV) Durvalumab q3w for four 21-day cycles as induction treatment. Durvalumab will also be given during the maintenance treatment period q4w until disease progression or unacceptable toxicity.
Tremelimumab
Participants will receive IV Tremelimumab q3w for four 21-days cycles as induction treatment. Tremelimumab will also be given during the maintenance therapy phase at week 16 and week 104 (at the investigators discretion).
Pemetrexed
Participants in Arm A and Arm B will receive IV pemetrexed q3w for four 21-day cycles as induction treatment. In the maintenance therapy phase, Treatment Arm A will receive Pemetrexed q4w, Treatment Arm B will receive Pemetrexed q3w until disease progression or unacceptable toxicity.
Pembrolizumab
Participants will receive IV pembrolizumab q3w for four 21-days cycles as induction treatment. Pembrolizumab will also be given in the maintenance treatment phase q3w until disease progression or unacceptable toxicity or up to 24 months.
Carboplatin
Participants will receive IV Carboplatin or IV Cisplatin on Day 1 of each 21-day cycle for 4 cycles as induction treatment.
Cisplatin
Participants will receive IV Carboplatin or IV Cisplatin on Day 1 of each 21-day cycle for 4 cycles as induction treatment.
WITHDRAWN
Research Site, New York
RECRUITING
Research Site, New York
RECRUITING
Research Site, New York
RECRUITING
Research Site, New York
RECRUITING
Research Site, The Bronx
RECRUITING
Research Site, The Bronx
RECRUITING
Research Site, New Hyde Park
WITHDRAWN
Research Site, Mineola
RECRUITING
Research Site, Westbury
RECRUITING
Research Site, Northport
RECRUITING
Research Site, Stony Brook
RECRUITING
Research Site, Shirley
RECRUITING
Research Site, Clifton Park
RECRUITING
Research Site, Albany
RECRUITING
Research Site, East Syracuse
RECRUITING
Research Site, Syracuse
RECRUITING
Research Site, Pittsburgh
RECRUITING
Research Site, Hershey
WITHDRAWN
Research Site, Philadelphia
WITHDRAWN
Research Site, Philadelphia
RECRUITING
Research Site, Washington D.C.
RECRUITING
Research Site, Washington D.C.
RECRUITING
Research Site, Bethesda
RECRUITING
Research Site, Fairfax
WITHDRAWN
Research Site, Charlottesville
RECRUITING
Research Site, Richmond
WITHDRAWN
Research Site, Atlanta
RECRUITING
Research Site, Atlanta
RECRUITING
Research Site, Atlanta
RECRUITING
Research Site, Albany
RECRUITING
Research Site, Columbus
RECRUITING
Research Site, Orlando
RECRUITING
Research Site, Fort Lauderdale
RECRUITING
Research Site, Jupiter
RECRUITING
Research Site, Tampa
WITHDRAWN
Research Site, Tampa
RECRUITING
Research Site, St. Petersburg
RECRUITING
Research Site, Ocala
WITHDRAWN
Research Site, Birmingham
RECRUITING
Research Site, Nashville
WITHDRAWN
Research Site, Memphis
RECRUITING
Research Site, Memphis
RECRUITING
Research Site, Memphis
RECRUITING
Research Site, Louisville
RECRUITING
Research Site, Lexington
RECRUITING
Research Site, Columbus
RECRUITING
Research Site, Maumee
RECRUITING
Research Site, Perrysburg
WITHDRAWN
Research Site, Toledo
RECRUITING
Research Site, Cleveland
RECRUITING
Research Site, Cleveland
RECRUITING
Research Site, Cleveland
RECRUITING
Research Site, Dayton
RECRUITING
Research Site, Dyer
RECRUITING
Research Site, Evansville
RECRUITING
Research Site, Detroit
WITHDRAWN
Research Site, Farmington Hills
WITHDRAWN
Research Site, Lansing
WITHDRAWN
Research Site, Traverse City
RECRUITING
Research Site, Milwaukee
RECRUITING
Research Site, Saint Paul
RECRUITING
Research Site, Sioux Falls
RECRUITING
Research Site, Bismarck
RECRUITING
Research Site, Billings
NOT_YET_RECRUITING
Research Site, Maywood
RECRUITING
Research Site, Chicago
WITHDRAWN
Research Site, Chicago
RECRUITING
Research Site, Urbana
RECRUITING
Research Site, Carterville
RECRUITING
Research Site, St Louis
RECRUITING
Research Site, St Louis
RECRUITING
Research Site, Kansas City
RECRUITING
Research Site, Kansas City
RECRUITING
Research Site, Westwood
RECRUITING
Research Site, Lincoln
RECRUITING
Research Site, Grand Island
RECRUITING
Research Site, Norman
RECRUITING
Research Site, Dallas
WITHDRAWN
Research Site, Dallas
RECRUITING
Research Site, Fort Worth
RECRUITING
Research Site, Denton
RECRUITING
Research Site, Houston
RECRUITING
Research Site, Houston
RECRUITING
Research Site, Kingwood
WITHDRAWN
Research Site, San Antonio
RECRUITING
Research Site, San Antonio
RECRUITING
Research Site, Austin
RECRUITING
Research Site, Wheat Ridge
RECRUITING
Research Site, Denver
WITHDRAWN
Research Site, Chandler
RECRUITING
Research Site, Tucson
RECRUITING
Research Site, Los Angeles
WITHDRAWN
Research Site, Los Angeles
RECRUITING
Research Site, Beverly Hills
RECRUITING
Research Site, Santa Monica
RECRUITING
Research Site, Los Alamitos
RECRUITING
Research Site, La Jolla
RECRUITING
Research Site, Loma Linda
RECRUITING
Research Site, Irvine
RECRUITING
Research Site, Redding
RECRUITING
Research Site, Honolulu
RECRUITING
Research Site, Anchorage
RECRUITING
Research Site, Jamaica Plain
RECRUITING
Research Site, Worcester
WITHDRAWN
Research Site, Providence
Lead Sponsor
AstraZeneca
INDUSTRY