Low Dose Versus High Dose Methylene Blue in Septic Patients

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

August 1, 2023

Primary Completion Date

April 29, 2024

Study Completion Date

May 15, 2024

Conditions
Septic Shock
Interventions
DRUG

Normal saline

100 ml 0.9% Nacl over 20 minutes, followed by continuous infusion of normal saline for 72 hours.

DRUG

Methylene Blue low dose

A bolus of MB 1mg/kg in 100ml 0.9% Nacl over 20 minutes followed by continuous infusion of 0.25mg/kg/hour for 72 hours.

DRUG

Methylene Blue high dose

A bolus of MB 4mg/kg in 100ml 0.9% Nacl over 20 minutes followed by continuous infusion of 0.25mg/kg/hour for 72 hours.

Trial Locations (1)

12588

National Cancer Institute, Cairo

All Listed Sponsors
lead

National Cancer Institute, Egypt

OTHER