Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

PHASE1RecruitingINTERVENTIONAL
Enrollment

171

Participants

Timeline

Start Date

February 22, 2024

Primary Completion Date

August 31, 2026

Study Completion Date

August 31, 2027

Conditions
AMLAML With Mutated NPM1Hematologic MalignancyKMT2ArNPM1 MutationMLL RearrangementLeukemiaAcute Myeloid LeukemiaLeukemia, MyeloidLeukemia, Myeloid, AcuteAcute LeukemiaNeoplasms by Histologic Type
Interventions
DRUG

Ziftomenib

Oral administration

DRUG

Fludarabine

Intravenous infusion

DRUG

Idarubicin

Intravenous infusion

DRUG

Cytarabine

Intravenous Infusion

DRUG

Gilteritinib

Oral administration

BIOLOGICAL

Granulocyte colony-stimulating factor

Subcutaneous injection

Trial Locations (43)

10021

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10065

RECRUITING

Weill Cornell Medical College-NY Presbyterian Hospital, New York

11042

RECRUITING

Northwell Health, LLC PRIME, Lake Success

11794

RECRUITING

Stony Brook Cancer Center, Stony Brook

14263

RECRUITING

Roswell Park Comprehensive Cancer Center, Buffalo

14642

RECRUITING

Wilmot Cancer Institute, University of Rochester, Rochester

18103

RECRUITING

Lehigh Valley Topper Cancer Institute, Allentown

22903

RECRUITING

University of Virginia Comprehensive Cancer Center, Charlottesville

29615

RECRUITING

Prisma Health, Greenville

30322

RECRUITING

Emory Healthcare - The Emory Clinic, Atlanta

30912

RECRUITING

Georgia Cancer Center at Augusta University, Augusta

33011

RECRUITING

Hospital Universitario Central de Asturias, Oviedo

37232

RECRUITING

Vanderbilt University Medical Center, Nashville

40138

RECRUITING

IRCCS Azienda Ospedaliero-Universitaria do Bologna - Policlinico di Sant'Orsola, Bologna

41013

RECRUITING

Hospital Universitario Virgen del Rocío, Seville

44106

RECRUITING

UH Seidman Cancer Center, Cleveland

46026

RECRUITING

Hospital Universitari y Politecnic La Fe, Valencia

48121

RECRUITING

Ospedale Santa Maria delle Croci, Ravenna

48201

RECRUITING

Karmanos Cancer Institute, Detroit

48202

RECRUITING

Henry Ford Cancer Institute, Detroit

52242

RECRUITING

University of Iowa Hospitals & Clinics, Iowa City

53226

RECRUITING

Froedtert & Medical College Clinics, Milwaukee

60153

RECRUITING

Loyola University Medical Center, Maywood

60201

RECRUITING

Atrium Health Levine Cancer Center, Charlotte

60611

RECRUITING

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago

62702

RECRUITING

Simmons Cancer Institute, Springfield

66160

RECRUITING

The University of Kansas Cancer Center, Kansas City

68198

RECRUITING

University of Nebraska Medical Center, Omaha

73104

RECRUITING

OU Health Stephenson Cancer Center, Oklahoma City

75246

RECRUITING

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas

77030

RECRUITING

MD Anderson Cancer Center, Houston

80218

RECRUITING

Colorado Blood Cancer Institute, Denver

85234

RECRUITING

Banner MD Anderson Cancer Center, Gilbert

90089

RECRUITING

USC Norris Comprehensive Cancer Center, Los Angeles

90095

RECRUITING

UCLA Health - Bowyer Oncology Center, Los Angeles

92868

RECRUITING

UC Irvine Health Chao Family Comprehensive Cancer Center, Orange

94115

RECRUITING

University of California San Francisco, San Francisco

98109

RECRUITING

University of Washington, Seattle

06511

RECRUITING

Smilow Cancer Hospital at Yale New Haven, New Haven

07601

RECRUITING

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack

05401

RECRUITING

University of Vermont, Burlington

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma

08035

RECRUITING

Hospital Universitari Vall d'Hebron, Barcelona

Sponsors
All Listed Sponsors
lead

Kura Oncology, Inc.

INDUSTRY