Study on Optimal Temperature During Cardiopulmonary Bypass (THERMIC-4)

NARecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

May 20, 2024

Primary Completion Date

November 30, 2025

Study Completion Date

February 28, 2026

Conditions
Ischemic Heart DiseaseValvular Heart DiseaseCardiovascular DiseasesSurgery-Complications
Interventions
PROCEDURE

Hypothermic Cardiopulmonary Bypass

Mild hypothermia (between 32 - 35 °C) during cardiopulmonary bypass

PROCEDURE

Normothermic Cardiopulmonary Bypass

Normothermia (active maintenance of temperature between 36.5 °C to 37.5°C; no active cooling below 36.5 °C) during cardiopulmonary bypass

Trial Locations (11)

LE3 9QP

RECRUITING

Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester

FY3 8NR

NOT_YET_RECRUITING

Blackpool Victoria Hospital, Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool

BS1 3NU

RECRUITING

University Hospitals Bristol and Weston NHS Foundation Trust, Bristol

HU16 5JQ

RECRUITING

Castle Hill Hospital, Hull University Teaching Hospitals NHS Trust, Cottingham

G81 4DY

RECRUITING

Golden Jubilee National Hospital, NHS Golden Jubilee, Glasgow

SE5 9RS

RECRUITING

King's College Hospital, King's College Hospital NHS Foundation Trust, London

SW3 6NP

NOT_YET_RECRUITING

Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London

UB9 6JH

NOT_YET_RECRUITING

Harefield Hospital, Guy's and St Thomas' NHS Foundation Trust, London

OX3 9DU

RECRUITING

John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford

PL6 8DH

RECRUITING

Derriford Hospital, Plymouth University Hospitals NHS Trust, Plymouth

S5 7AU

RECRUITING

Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield

All Listed Sponsors
collaborator

NHS National Waiting Times Centre Board

OTHER

collaborator

Sheffield Teaching Hospitals NHS Foundation Trust

OTHER

collaborator

Oxford University Hospitals NHS Trust

OTHER

collaborator

Hull University Teaching Hospitals NHS Trust

OTHER_GOV

collaborator

University Hospitals Bristol and Weston NHS Foundation Trust

OTHER

collaborator

University Hospitals, Leicester

OTHER

collaborator

Royal Brompton & Harefield NHS Foundation Trust

OTHER

collaborator

King's College Hospital NHS Trust

OTHER

collaborator

University Hospital Plymouth NHS Trust

OTHER

lead

University of Leicester

OTHER