A Study of AK104/Tislelizumab With Chemotherapy as First-line Treatment in PD-L1 TPS < 1% Non-small Cell Lung Cancer

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

642

Participants

Timeline

Start Date

November 14, 2023

Primary Completion Date

August 5, 2025

Study Completion Date

November 28, 2026

Conditions
Locally Advanced or Metastatic NSCLC
Interventions
DRUG

AK104

AK104 IV, q3w

DRUG

Tislelizumab

Tislelizumab IV, q3w

DRUG

carboplatin

carboplatin IV, q3w

DRUG

Pemetrexed

Pemetrexed IV, q3w (for Nonsquamous NSCLC)

DRUG

Paclitaxel

Paclitaxel IV, q3w (for squamous NSCLC)

Trial Locations (62)

45310

The First Affiliated Hospital of Xinxiang Medical College, Xinxiang

100021

Cancer hospital, Chinese academy of medical sciences and Peking union medical college, Beijing

100039

The Fifth Medical Center of the Chinese People's Liberation Army General Hospital, Beijing

100142

Beijing Cancer Hospital, Beijing

101149

Beijing Chest hospital, Beijing

110002

The First Hospital of China medical University, Shenyang

110801

Liaoning cancer hospital, Shenyang

130061

The first hospital of Jilin Universit, Changchun

134099

Tonghua Central Hospital, Tonghua

150081

Harbin medical university cancer hospital, Harbin

154007

Jiamusi Tuberculosis Prevention and Control Hospital (Jiamusi Cancer Hospital), Jiamusi

161005

The first hospital of Qiqihar, Qiqihar

200032

Zhongshan Hospital, Fudan university, Shanghai

215006

The First Affiliated Hospital of Soochow University, Suzhou

221799

The affiliated hospital of xuzhou medical university, Xuzhou

230001

Anhui provincial hospital, Hefei

230088

Anhui provincial cancer hospital, Hefei

233099

The first affiliated hospital of bengbu medical college, Bengbu

241001

The first affiliated hospital of wannan medical college, Wuhu

250117

Shandong Cancer Hospital, Jinan

256603

Binzhou medical university hospital, Binzhou

261041

Weifang NO.2 people's Hospital, Weifang

266000

The Affiliated Hospital of Qingdao University, Qingdao

300060

Tianjin Medical University Cancer Institute & Hospital, Tianjin

300222

Tianjin Chest Hospital, Tianjin

310003

The First Affiliated Hospital, Zhejiang University School of Medicine (FAHZU), Hangzhou

310005

Zhejiang Cancer Hospital, Hangzhou

330006

First Affiliated Hospital of Nanchang University, Nanchang

341000

First Affiliated Hospital of Gannan medical college, Ganzhou

350014

Fujian cancer hospital, Fuzhou

363099

Zhangzhou municipal hospital of fujian province, Zhangzhou

400030

Chongqing University Cancer Hospital, Chongqing

410008

Xiangya Hospital of Central South University, Changsha

410012

The Second Xiangya Hospital, Central South University, Changsha

410013

Hunan Cancer Hospital, Changsha

430060

Renmin Hospital of Wuhan University, Wuhan

430079

Hubei Cancer Hospital, Wuhan

450003

Henan Cancer Hospital, Zhengzhou

450052

The First Affiliated Hospital of Henan University of Science and Technology, Luoyang

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

473005

Nanyang central hospital, Nanyang

510080

The First Affiliated Hospital of Sun Yat-sen University, Guangzhou

510095

Affiliated cancer hospital and institute of guangzhou medical university, Guangzhou

510515

Nanfang hospital, Guangzhou

518172

Cancer hospital Chinses academy of medical sciences, shenzhen center, Shenzhen

570312

Hainan cancer hospital, Haikou

610042

Sichuan Cancer Hospital, Chengdu

621099

Mianyang central hospital, Mianyang

644000

The Second People's Hospital of Yibin City, Yibin

650118

Yunnan Cancer Hospital /the Third Affiliated Hospital of Kunming Medical University, Kunming

710061

The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an

730050

Gansu provincial cancer hospital, Lanzhou

750003

General hospital of ningxia medical university, Yinchuan

810012

Qinghai university affiliated hospital, Xining

830000

Xinjiang Medical University Cancer Hospital, Ürümqi

050031

Affiliated hospital of Hebei university, Baoding

053099

The second people's hospital of Hengshui, Hengshui

050004

The Second Hospital of HeBei Medical University, Shijiazhuang

050011

The Fourth Hospital of Hebei Medical University, Shijiazhuang

063001

Tangshang people's hospital, Tangshan

046099

Changzhi people's hospital, Changzhi

030013

Shanxi Cancer hospital, Taiyuan

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Akeso

INDUSTRY