Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

56

Participants

Timeline

Start Date

March 7, 2024

Primary Completion Date

January 31, 2026

Study Completion Date

January 31, 2027

Conditions
Lung CancerNSCLCBrain Metastases
Interventions
DRUG

Alectinib

600mg taken orally, twice daily for 25 Cycles Cycle = 4 weeks (28 days)

RADIATION

Stereotactic Radiosurgery

SRS dose varies by brain met size and location

Trial Locations (3)

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

80045

RECRUITING

University of Colorado Cancer Center, Aurora

94305

RECRUITING

Stanford University, Stanford

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

lead

Joshua Palmer

OTHER