Optimal Timing of Euploid Day 6 Blastocyst Transfer in Frozen HRT Cycles, Day 6 or Day 7 of Progesterone Administration.

PHASE1RecruitingINTERVENTIONAL
Enrollment

316

Participants

Timeline

Start Date

September 22, 2023

Primary Completion Date

December 30, 2025

Study Completion Date

December 30, 2025

Conditions
InfertilityFertility IssuesInfertility, Female
Interventions
DIAGNOSTIC_TEST

Transvaginal ultrasound

Transvaginal ultrasound throughout the HRT cycle to not only monitor endometrial development but to also exclude the presence of an ovarian dominant follicle

DIAGNOSTIC_TEST

Serum LH, E2, P4

In conjunction with ultrasound monitoring, participants will undergo serial measurements of serum Luteinizing Hormone (LH), Estradiol (E2) and Progesterone (P4) levels

DRUG

Estradiol Valerate 2 MG

"Participants will commence estradiol valerate 4 mg ( 2 x 2 mg) on day 2 / day 3 of menses.~Estradiol will be increased to 6 mg on day 2 of estrogen treatment, and continued at a daily dose of 6 mg (3 tablets daily)"

DRUG

Progesterone 100 Mg Vaginal Insert

The initial progesterone dose of 100 mg will be commenced at 13hrs and repeated at 21hrs considered day 1 (vaginal suppository) when an optimal endometrial thickness for each participant has been achieved with a trilaminar appearance. The following day (day 2) progesterone administration will be increased to 100 mg vaginally three times daily

DIAGNOSTIC_TEST

Serum P4 day of ET

On the day of embryo transfer (ET), a blood test is taken to measure serum P4

PROCEDURE

Embryo transfer

Procedure in which embryo is transferred into the uterus

Trial Locations (2)

60202

RECRUITING

ART Fertility Clinics LLC, Abu Dhabi

Unknown

RECRUITING

ART Fertility Clinics Dubai, Dubai

All Listed Sponsors
lead

ART Fertility Clinics LLC

OTHER