CT for Personalized Mechanical Ventilation

NAActive, not recruitingINTERVENTIONAL
Enrollment

7

Participants

Timeline

Start Date

May 10, 2023

Primary Completion Date

August 31, 2027

Study Completion Date

August 31, 2027

Conditions
Ventilator-Induced Lung InjurySepsis SyndromeMechanical Ventilation Complication
Interventions
PROCEDURE

PEEP (positive end-expiratory pressure) - maximum

"Breathing assistance from the breathing assist machine using a method in which doctors try to find the pressures that expands the lungs the best. This is based on measurements of one's respiratory pressures and volumes. This is done by adjusting the pressure settings. This allows one's lungs to expand with the least amount of change in pressure during breathing.~PEEP (positive end-expiratory pressure) will be set at the maximum static respiratory system compliance (Crs) during a descending PEEP titration curve."

PROCEDURE

PEEP (positive end-expiratory pressure) - standard

"Breathing assistance from the breathing assist machine using the pressure settings typical for your disease.~Standard ARDSNet low-stretch PEEP (positive end-expiratory pressure) protocol: PEEP will be set following a routinely used PEEP table according to patients' blood oxygenation status."

Trial Locations (1)

10025

Columbia University, New York

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Columbia University

OTHER