421
Participants
Start Date
October 20, 2023
Primary Completion Date
August 31, 2038
Study Completion Date
August 31, 2038
Zanubrutinib
Given PO
Rituximab
Given IV
Patient Observation
Undergo observation
Bone Marrow Biopsy
undergo bone marrow biopsy
Fludeoxyglucose F-18
Given IV
Positron Emission Tomography
Undergo PET
Computed Tomography
Undergo CT
Magnetic Resonance Imaging
Undergo MRI
Esophagogastroduodenoscopy
Undergo EGD
Colonoscopy
Undergo colonoscopy
Biospecimen Collection
Undergo blood sample collection
Questionnaire Administration
Ancillary studies
RECRUITING
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
RECRUITING
NYP/Weill Cornell Medical Center, New York
RECRUITING
NYU Langone Hospital - Long Island, Mineola
RECRUITING
Hematology Oncology Associates of CNY at Camillus, Camillus
RECRUITING
Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse
RECRUITING
Roswell Park Cancer Institute, Buffalo
RECRUITING
Wilmot Cancer Institute at Webster, Webster
RECRUITING
University of Rochester, Rochester
RECRUITING
Helen F Graham Cancer Center, Newark
RECRUITING
Medical Oncology Hematology Consultants PA, Newark
RECRUITING
VCU Massey Cancer Center at Stony Point, Richmond
RECRUITING
VCU Massey Comprehensive Cancer Center, Richmond
RECRUITING
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
RECRUITING
Duke University Medical Center, Durham
RECRUITING
Prisma Health Cancer Institute - Spartanburg, Boiling Springs
RECRUITING
Medical University of South Carolina, Charleston
RECRUITING
Prisma Health Cancer Institute - Butternut, Greenville
RECRUITING
Prisma Health Cancer Institute - Faris, Greenville
RECRUITING
Prisma Health Cancer Institute - Eastside, Greenville
RECRUITING
Prisma Health Cancer Institute - Easley, Easley
RECRUITING
Prisma Health Cancer Institute - Greer, Greer
RECRUITING
Prisma Health Cancer Institute - Seneca, Seneca
RECRUITING
Emory Johns Creek Hospital, Johns Creek
RECRUITING
Grady Health System, Atlanta
RECRUITING
Emory University Hospital Midtown, Atlanta
RECRUITING
Emory University Hospital/Winship Cancer Institute, Atlanta
RECRUITING
Emory Saint Joseph's Hospital, Atlanta
RECRUITING
Augusta University Medical Center, Augusta
RECRUITING
Ohio State University Comprehensive Cancer Center, Columbus
RECRUITING
Northwest Cancer Center - Main Campus, Crown Point
RECRUITING
Northwest Oncology LLC, Dyer
RECRUITING
Saint Catherine Hospital, Indianapolis
RECRUITING
The Community Hospital, Munster
RECRUITING
Women's Diagnostic Center - Munster, Munster
RECRUITING
Northwest Cancer Center - Hobart, Hobart
RECRUITING
Saint Mary Medical Center, Hobart
RECRUITING
Northwest Cancer Center - Valparaiso, Valparaiso
RECRUITING
Henry Ford Saint John Hospital - Macomb Medical, Macomb
RECRUITING
Corewell Health William Beaumont University Hospital, Royal Oak
RECRUITING
Corewell Health Beaumont Troy Hospital, Troy
RECRUITING
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
RECRUITING
Huron Gastroenterology PC, Ypsilanti
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton
RECRUITING
Trinity Health Medical Center - Brighton, Brighton
RECRUITING
Chelsea Hospital, Chelsea
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea
RECRUITING
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton
RECRUITING
Trinity Health Medical Center - Canton, Canton
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti
RECRUITING
Wayne State University/Karmanos Cancer Institute, Detroit
RECRUITING
Weisberg Cancer Treatment Center, Farmington Hills
RECRUITING
Corewell Health Farmington Hills Hospital, Farmington Hills
RECRUITING
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac
RECRUITING
McLaren Cancer Institute-Clarkston, Clarkston
RECRUITING
McLaren Cancer Institute-Lapeer Region, Lapeer
RECRUITING
Cancer Hematology Centers - Flint, Flint
SUSPENDED
Genesee Hematology Oncology PC, Flint
RECRUITING
Genesys Hurley Cancer Institute, Flint
RECRUITING
Hurley Medical Center, Flint
RECRUITING
McLaren Cancer Institute-Flint, Flint
RECRUITING
MyMichigan Medical Center Saginaw, Saginaw
SUSPENDED
Oncology Hematology Associates of Saginaw Valley PC, Saginaw
SUSPENDED
Saint Mary's Oncology/Hematology Associates of West Branch, West Branch
RECRUITING
McLaren Cancer Institute-Bay City, Bay City
RECRUITING
MyMichigan Medical Center Tawas, Tawas City
RECRUITING
McLaren Cancer Institute-Central Michigan, Mount Pleasant
RECRUITING
McLaren Cancer Institute-Northern Michigan, Petoskey
RECRUITING
Mary Greeley Medical Center, Ames
RECRUITING
McFarland Clinic - Ames, Ames
RECRUITING
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny
RECRUITING
McFarland Clinic - Boone, Boone
RECRUITING
McFarland Clinic - Jefferson, Jefferson
RECRUITING
McFarland Clinic - Marshalltown, Marshalltown
RECRUITING
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee
RECRUITING
Iowa Methodist Medical Center, Des Moines
RECRUITING
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines
RECRUITING
Broadlawns Medical Center, Des Moines
RECRUITING
Mercy Medical Center - Des Moines, Des Moines
RECRUITING
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
RECRUITING
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
RECRUITING
McFarland Clinic - Trinity Cancer Center, Fort Dodge
RECRUITING
UI Healthcare Mission Cancer and Blood - Fort Dodge, Fort Dodge
RECRUITING
Saint Anthony Regional Hospital, Carroll
RECRUITING
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
RECRUITING
University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek
RECRUITING
ProHealth Oconomowoc Memorial Hospital, Oconomowoc
RECRUITING
ProHealth D N Greenwald Center, Mukwonago
RECRUITING
Froedtert and MCW Moorland Reserve Health Center, New Berlin
RECRUITING
UW Cancer Center at ProHealth Care, Waukesha
RECRUITING
Medical College of Wisconsin, Milwaukee
RECRUITING
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison
RECRUITING
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
RECRUITING
Marshfield Medical Center-Marshfield, Marshfield
RECRUITING
Marshfield Medical Center - Weston, Weston
RECRUITING
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
RECRUITING
Marshfield Medical Center - Minocqua, Minocqua
RECRUITING
Gundersen Lutheran Medical Center, La Crosse
RECRUITING
Marshfield Medical Center-EC Cancer Center, Eau Claire
RECRUITING
Duluth Clinic Ashland, Ashland
RECRUITING
Marshfield Medical Center-Rice Lake, Rice Lake
RECRUITING
Essentia Health Sandstone, Sandstone
RECRUITING
Regions Hospital, Saint Paul
RECRUITING
United Hospital, Saint Paul
RECRUITING
Saint John's Hospital - Healtheast, Maplewood
RECRUITING
Minnesota Oncology Hematology PA-Woodbury, Woodbury
RECRUITING
Abbott-Northwestern Hospital, Minneapolis
RECRUITING
Hennepin County Medical Center, Minneapolis
RECRUITING
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
RECRUITING
Mercy Hospital, Coon Rapids
RECRUITING
Essentia Health Hibbing Clinic, Hibbing
RECRUITING
Essentia Health Virginia Clinic, Virginia
RECRUITING
Essentia Health Cancer Center, Duluth
RECRUITING
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud
RECRUITING
Essentia Health Saint Joseph's Medical Center, Brainerd
RECRUITING
Sanford Joe Lueken Cancer Center, Bemidji
RECRUITING
Essentia Health - Deer River Clinic, Deer River
RECRUITING
Sanford Cancer Center Oncology Clinic, Sioux Falls
RECRUITING
Essentia Health Cancer Center-South University Clinic, Fargo
RECRUITING
Sanford Broadway Medical Center, Fargo
RECRUITING
Sanford Roger Maris Cancer Center, Fargo
RECRUITING
Sanford Bismarck Medical Center, Bismarck
RECRUITING
Billings Clinic Cancer Center, Billings
RECRUITING
Benefis Sletten Cancer Institute, Great Falls
RECRUITING
Community Hospital of Anaconda, Anaconda
RECRUITING
Bozeman Health Deaconess Hospital, Bozeman
RECRUITING
Community Medical Center, Missoula
RECRUITING
Logan Health Medical Center, Kalispell
RECRUITING
University of Illinois, Chicago
RECRUITING
Illinois CancerCare-Dixon, Dixon
RECRUITING
Illinois CancerCare-Ottawa Clinic, Ottawa
RECRUITING
Illinois CancerCare-Peru, Peru
RECRUITING
Illinois CancerCare-Princeton, Princeton
RECRUITING
Illinois CancerCare-Galesburg, Galesburg
RECRUITING
Illinois CancerCare-Kewanee Clinic, Kewanee
RECRUITING
Illinois CancerCare-Macomb, Macomb
RECRUITING
Illinois CancerCare-Canton, Canton
RECRUITING
Illinois CancerCare-Eureka, Eureka
RECRUITING
Illinois CancerCare-Pekin, Pekin
RECRUITING
Illinois CancerCare - Washington, Washington
RECRUITING
Illinois CancerCare-Peoria, Peoria
RECRUITING
Illinois CancerCare-Bloomington, Bloomington
RECRUITING
Carle Cancer Center, Urbana
RECRUITING
Carle at The Riverfront, Danville
RECRUITING
Carle Physician Group-Mattoon/Charleston, Mattoon
RECRUITING
Cancer Care Center of O'Fallon, O'Fallon
RECRUITING
Memorial Hospital East, Shiloh
RECRUITING
Illinois CancerCare-Carthage, Carthage
RECRUITING
Carle Physician Group-Effingham, Effingham
RECRUITING
Crossroads Cancer Center, Effingham
RECRUITING
Cancer Care Specialists of Illinois - Decatur, Decatur
RECRUITING
Decatur Memorial Hospital, Decatur
RECRUITING
Southern Illinois University School of Medicine, Springfield
RECRUITING
Springfield Clinic, Springfield
RECRUITING
Springfield Memorial Hospital, Springfield
RECRUITING
Saint Luke's Hospital, Chesterfield
RECRUITING
Washington University School of Medicine, St Louis
RECRUITING
Mercy Hospital South, St Louis
RECRUITING
Siteman Cancer Center-South County, St Louis
RECRUITING
Siteman Cancer Center at Christian Hospital, St Louis
RECRUITING
Siteman Cancer Center at West County Hospital, Creve Coeur
RECRUITING
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
RECRUITING
Saint Francis Medical Center, Cape Girardeau
RECRUITING
University of Kansas Cancer Center - Lee's Summit, Lee's Summit
RECRUITING
University Health Truman Medical Center, Kansas City
SUSPENDED
University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City
RECRUITING
University of Kansas Cancer Center - North, Kansas City
RECRUITING
Mercy Hospital Springfield, Springfield
RECRUITING
CoxHealth South Hospital, Springfield
RECRUITING
Lawrence Memorial Hospital, Lawrence
RECRUITING
The University of Kansas Cancer Center - Olathe, Olathe
RECRUITING
University of Kansas Cancer Center, Kansas City
RECRUITING
University of Kansas Hospital-Westwood Cancer Center, Westwood
RECRUITING
University of Kansas Cancer Center-Overland Park, Overland Park
RECRUITING
University of Kansas Health System Saint Francis Campus, Topeka
RECRUITING
Freeman Physician Group of Pittsburg, Pittsburg
RECRUITING
Salina Regional Health Center, Salina
RECRUITING
HaysMed, Hays
RECRUITING
Nebraska Medicine-Village Pointe, Omaha
RECRUITING
Nebraska Medicine-Bellevue, Bellevue
RECRUITING
University of Nebraska Medical Center, Omaha
RECRUITING
University of Arkansas for Medical Sciences, Little Rock
RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
Cancer Centers of Southwest Oklahoma Research, Lawton
RECRUITING
Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa
RECRUITING
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell
RECRUITING
Saint Luke's Cancer Institute - Fruitland, Fruitland
RECRUITING
Saint Luke's Cancer Institute - Meridian, Meridian
RECRUITING
Saint Alphonsus Cancer Care Center-Nampa, Nampa
RECRUITING
Saint Luke's Cancer Institute - Nampa, Nampa
RECRUITING
Saint Alphonsus Cancer Care Center-Boise, Boise
RECRUITING
Saint Luke's Cancer Institute - Boise, Boise
RECRUITING
Kootenai Health - Coeur d'Alene, Coeur d'Alene
RECRUITING
Kootenai Clinic Cancer Services - Post Falls, Post Falls
RECRUITING
Kootenai Clinic Cancer Services - Sandpoint, Sandpoint
RECRUITING
Huntsman Cancer Institute/University of Utah, Salt Lake City
RECRUITING
Cedars Sinai Medical Center, Los Angeles
RECRUITING
Tower Cancer Research Foundation, Beverly Hills
RECRUITING
City of Hope Comprehensive Cancer Center, Duarte
RECRUITING
City of Hope at Irvine Lennar, Irvine
RECRUITING
Providence Willamette Falls Medical Center, Oregon City
RECRUITING
Providence Newberg Medical Center, Newberg
RECRUITING
Providence Portland Medical Center, Portland
RECRUITING
Providence Saint Vincent Medical Center, Portland
RECRUITING
Saint Alphonsus Cancer Care Center-Ontario, Ontario
RECRUITING
Swedish Cancer Institute-Edmonds, Edmonds
RECRUITING
Swedish Cancer Institute-Issaquah, Issaquah
RECRUITING
Swedish Medical Center-First Hill, Seattle
RECRUITING
Smilow Cancer Hospital-Derby Care Center, Derby
RECRUITING
Smilow Cancer Hospital Care Center-Fairfield, Fairfield
RECRUITING
Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury
RECRUITING
Smilow Cancer Hospital Care Center at Greenwich, Greenwich
RECRUITING
Smilow Cancer Hospital Care Center - Guilford, Guilford
RECRUITING
Smilow Cancer Hospital Care Center at Saint Francis, Hartford
RECRUITING
Yale University, New Haven
RECRUITING
Yale-New Haven Hospital North Haven Medical Center, North Haven
RECRUITING
Smilow Cancer Hospital Care Center at Long Ridge, Stamford
RECRUITING
Smilow Cancer Hospital-Torrington Care Center, Torrington
RECRUITING
Smilow Cancer Hospital Care Center-Trumbull, Trumbull
RECRUITING
Smilow Cancer Hospital-Waterbury Care Center, Waterbury
RECRUITING
Smilow Cancer Hospital Care Center - Waterford, Waterford
RECRUITING
Alliance for Clinical Trials in Oncology, Boston
RECRUITING
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
RECRUITING
Rhode Island Hospital, Providence
RECRUITING
Smilow Cancer Hospital Care Center - Westerly, Westerly
RECRUITING
Sanford USD Medical Center - Sioux Falls, Sioux Falls
RECRUITING
Dartmouth Cancer Center - North, Saint Johnsbury
National Cancer Institute (NCI)
NIH
Alliance for Clinical Trials in Oncology
OTHER