A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC

PHASE2RecruitingINTERVENTIONAL
Enrollment

260

Participants

Timeline

Start Date

October 18, 2023

Primary Completion Date

January 1, 2031

Study Completion Date

January 1, 2031

Conditions
Adenocarcinoma, Pancreatic Ductal
Interventions
DRUG

Autogene cevumeran

Autogene cevumeran will be administered intravenously (IV) at a recommended dose at specified timepoints.

DRUG

Atezolizumab

Atezolizumab will be administered IV at a dose of 1680 milligrams (mg) at specified timepoints.

DRUG

mFOLFIRINOX

mFOLFIRINOX (oxaliplatin, leucovorin, irinotecan, 5-FU) will be administered IV at specified timepoints.

Trial Locations (88)

1070

RECRUITING

ULB Hôpital Erasme, Brussels

2650

RECRUITING

Antwerp University Hospital, Edegem

3000

RECRUITING

UZ Leuven, Leuven

9000

RECRUITING

AZ Maria Middelares, Ghent

RECRUITING

Universitair Ziekenhuis Gent, Ghent

10016

RECRUITING

NYU Langone Health, New York

10029

RECRUITING

Mount SInai Medical Center, New York

10032

RECRUITING

Columbia University Medical Center, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10604

RECRUITING

Memorial Sloan Kettering Cancer Center at Westchester, Harrison

11042

RECRUITING

Northwell Health, Lake Success

11553

RECRUITING

Memorial Sloan Kettering Cancer Center at Nassau, Uniondale

11725

RECRUITING

Memorial Sloan Kettering Cancer Center - Commack, Commack

13273

RECRUITING

Institut Paoli Calmettes, Marseille

13353

RECRUITING

Charite-Universitaetsmedizin Berlin - Campus Virchow-Klinikum (CVK), Berlin

13496

RECRUITING

CHA Bundang Medical Center, Gyeonggi-do

13620

RECRUITING

Seoul National University Bundang Hospital, Seongnam-si

20246

RECRUITING

Universitätsklinikum Hamburg-Eppendorf, Hamburg

28007

RECRUITING

Hospital General Universitario Gregorio Marañon, Madrid

28027

RECRUITING

Clinica Universitaria de Navarra de Madrid;Servicio de Hepatologia, Madrid

28034

RECRUITING

Hospital Universitario Ramón y Cajal, Madrid

28041

RECRUITING

Hospital Universitario 12 De Octubre, Madrid

28050

RECRUITING

Centro Integral Oncológico Clara Campal Ensayos Clínicos START, Madrid

29010

RECRUITING

Hospital Regional Universitario de Malaga, Málaga

31008

RECRUITING

Clinica Universitaria de Navarra (CUN), Pamplona/iruña

33011

RECRUITING

Hospital Universitario Central de Asturias, Oviedo

40536

RECRUITING

University of Kentucky Medical Center, Lexington

44791

RECRUITING

Universitaetsklinikum der Ruhr-Universitaet Bochum (UKRUB), Bochum

45147

RECRUITING

Universitätsklinikum Essen, Essen

45219

RECRUITING

University of Cincinnati Cancer Institute, Cincinnati

46202

RECRUITING

Indiana University Health Melvin & Bren Simon Cancer Center, Indianapolis

48202

RECRUITING

Henry Ford Health System, Detroit

50937

RECRUITING

Universitaetsklinikum Koeln, Cologne

54519

RECRUITING

Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy

59037

RECRUITING

Centre Hospitalier Régional Universitaire de Lille, Lille

60488

RECRUITING

Krankenhaus Nordwest GmbH, Frankfurt

60611

RECRUITING

Northwestern Memorial Hospital, Chicago

69008

RECRUITING

Centre Leon Berard, Lyon

69120

RECRUITING

Universitaetsklinikum Heidelberg, Heidelberg

72076

RECRUITING

Universitaetsklinikum Tuebingen, Tübingen

81925

RECRUITING

Klinikum Bogenhausen, München

89081

RECRUITING

Universitätsklinikum Ulm, Klinik für Innere MedizinInnere Medizin III Studienzentrale, Ulm

90033

RECRUITING

USC Norris Comprehensive Cancer Center, Los Angeles

90095

RECRUITING

University of California Los Angeles, Los Angeles

92663

RECRUITING

USC Norris Cancer Center, Newport Beach

94158

RECRUITING

University of California, San Francisco (UCSF), San Francisco

94805

RECRUITING

Gustave Roussy, Villejuif

97080

RECRUITING

Uniklinikum Würzburg, Med. Klinik und Poliklinik II, Würzburg

98109

RECRUITING

Fred Hutchinson Cancer Research Center, Seattle

06105

RECRUITING

St. Francis Hospital and Medical Center, Hartford

06510

WITHDRAWN

Smilow Cancer Center, New Haven

06520

RECRUITING

Yale Cancer Center, New Haven

06611

RECRUITING

Smilow Cancer Hospital Care Center at Trumbull, Trumbull

02114-2621

RECRUITING

Harvard Medical School - Massachusetts General Hospital (MGH) - Cancer Center, Boston

02118

RECRUITING

Boston Medical Center (BMC) - Cancer Care Center, Boston

68198-5300

RECRUITING

University of Nebraska, Omaha

07920

RECRUITING

Memorial Sloan Kettering Cancer Center Basking Ridge, Basking Ridge

07748

RECRUITING

Memorial Sloan Kettering Cancer Center, Middletown

07645

RECRUITING

Memorial Sloan Kettering Cancer Center at Bergen, Montvale

10065-7471

RECRUITING

MEETH-LHH Northwell Health Cancer Clinical Trials Office at MEETH-LHH, New York

27710-4000

RECRUITING

Duke Cancer Institute, Durham

02903

RECRUITING

Rhode Island Hospital, Providence

02906

RECRUITING

Miriam Hospital, Providence

M5B 1W8

RECRUITING

St Michael Hospital, Toronto

M5G 2M9

RECRUITING

Princess Margaret Cancer Center, Toronto

H2L 4M1

RECRUITING

Centre Hospitalier de l'Universite de Montreal - Notre - Dame Hos pital, Montreal

H3T 1E2

RECRUITING

Jewish General Hospital, Montreal

01307

RECRUITING

Universitätsklinikum Carl Gustav Carus Dresden, Dresden

1081 HV

RECRUITING

Amsterdam UMC Location VUMC, Amsterdam

6500 HB

RECRUITING

UMC Radboud Nijmegen, Nijmegen

3000 CA

RECRUITING

Erasmus MC, Rotterdam

410-769

RECRUITING

National Cancer Center (NCC) Hospital - Center for Liver and Pancreatobiliary Cancer, Goyang-si

06591

RECRUITING

The Catholic University of Korea - Seoul St. Mary's Hospital (Kangnam St. Mary's Hospital), Seocho

06351

RECRUITING

Samsung Medical Center, Seoul

120-752

RECRUITING

Severance Hospital - Yonsei Cancer Center, Seoul

05505

RECRUITING

University of Ulsan College of Medicine - Asan Medical Center (AMC) - Asan Cancer Center (ACC), Songpa-gu

08916

RECRUITING

Institut Catala d?Oncologia Hospital Germans Trias i Pujol, Badalona

08035

RECRUITING

Hospital Universitario Vall d Hebron, Barcelona

41 343

RECRUITING

Sahlgrenska Universitetssjukhuset, Gothenburg

171 64

RECRUITING

Karolinska Universitetssjukhuset, Solna

BT9 7AB

RECRUITING

Belfast City Hospital, Belfast

B15 2TH

RECRUITING

University Hospitals Birmingham NHS Foundation Trust, Birmingham

CB2 0QQ

RECRUITING

Addenbrookes Hospital, Cambridge

L7 8XP

RECRUITING

Royal Liverpool University Hospital, Liverpool

EC1A 7BE

RECRUITING

Barts Health NHS Trust, London

SE1 9RT

RECRUITING

Guys Hospital, London

W12 0HS

RECRUITING

Hammersmith Hospital, London

WC1E 6DD

RECRUITING

University College London Cancer Institute, London

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

BioNTech SE

INDUSTRY

lead

Genentech, Inc.

INDUSTRY