Laryngoscopy for Neonatal and Infant Airway Management with Supplemental Oxygen At Different Flow Rates (OPTIMISE-2)

NARecruitingINTERVENTIONAL
Enrollment

1,192

Participants

Timeline

Start Date

December 1, 2023

Primary Completion Date

August 31, 2025

Study Completion Date

December 31, 2025

Conditions
Airway Management
Interventions
DEVICE

Low-flow nasal supplemental oxygen with a conventional nasal cannula during tracheal intubation with the C-MAC video laryngoscope

0.2 L/kg/min FiO2 1.0 low-flow nasal supplemental oxygen with a conventional nasal cannula during tracheal intubation with the C-MAC video laryngoscope (Karl Storz, Tuttlingen, Germany) with Miller-blade or Macintosh-blade size No. 0 or No. 1.

DEVICE

High-flow nasal supplemental oxygen (Fisher & Paykel, Auckland, New Zealand) during tracheal intubation with the C-MAC video laryngoscope

2 L/kg/min FiO2 1.0 high-flow nasal supplemental oxygen (Fisher \& Paykel, Auckland, New Zealand) during tracheal intubation with the C-MAC video laryngoscope (Karl Storz, Tuttlingen, Germany) with Miller-blade or Macintosh-blade size No. 0 or No. 1.

Trial Locations (6)

1011

RECRUITING

CHUV Centre Hospitalier Universitaire Vaudois, Lausanne

3010

RECRUITING

Inselspital, Bern

13353

RECRUITING

Deutsches Herzzentrum der Charité and Charité, Berlin

Unknown

RECRUITING

Dept. Anesthesia, The Hospital for Sick Children, Toronto

RECRUITING

Dept. Anesthesia, Montreal Children's Hospital, McGill University Health Centre, Montreal

RECRUITING

Department of Cardiac Anesthesiology and Intensive Care Medicine, Charité Universitätsmedizin, Berlin

All Listed Sponsors
collaborator

University Hospital, Geneva

OTHER

collaborator

Kantonsspital Aarau

OTHER

collaborator

Centre Hospitalier Universitaire Vaudois

OTHER

collaborator

Charite University, Berlin, Germany

OTHER

collaborator

Royal Perth Hospital

OTHER

collaborator

The Hospital for Sick Children

OTHER

collaborator

Istituto Giannina Gaslini

OTHER

lead

Thomas Riva

OTHER