Anti-Argonaute Antibodies for the Diagnosis of Sensory Neuronopathies

CompletedOBSERVATIONAL
Enrollment

630

Participants

Timeline

Start Date

May 27, 2021

Primary Completion Date

January 27, 2023

Study Completion Date

January 27, 2023

Conditions
Autoimmune Diseases
Interventions
DIAGNOSTIC_TEST

Diagnosis of sensitive neuronopathy - phase 1

Search of positivity with anti-AGO antibodies test

DIAGNOSTIC_TEST

Diagnosis of sensitive neuronopathy - phase 2

Title of anti-AGO antibodies

OTHER

Comparison with Chi2 method

Clinical data from positive Argonaute (AGO) patients (age, sex, type of neuropathy, clinical manifestations of neuropathy, electroneuromyography , evolution of neuropathy, presence of associated autoimmune disease, response to possible immunomodulatory treatment) will be compared with those of negative patients using a Chi2 method for qualitative data.

OTHER

Comparison of data with parametric Test (T-test)

Clinical data from positive Argonaute (AGO) patients (age, sex, type of neuropathy, clinical manifestations of neuropathy, electroneuromyography, evolution of neuropathy, presence of associated autoimmune disease, response to possible immunomodulatory treatment) will be compared with those of negative patients using a parametric test (T-test).

OTHER

Comparison of data with non-parametric test (ANNOVA)

Clinical data from positive Argonaute (AGO) patients (age, sex, type of neuropathy, clinical manifestations of neuropathy, electroneuromyography , evolution of neuropathy, presence of associated autoimmune disease, response to possible immunomodulatory treatment) will be compared with those of negative patients using a non-parametric (ANNOVA).

Trial Locations (1)

42055

CHU Saint-Etienne, Saint-Etienne

All Listed Sponsors
lead

Centre Hospitalier Universitaire de Saint Etienne

OTHER