1,230
Participants
Start Date
August 17, 2023
Primary Completion Date
August 30, 2025
Study Completion Date
October 30, 2025
Normobaric Hyperoxia
Within 4.5 hours after stroke onset, patients were randomized into the NBO group and immediately given 100% oxygen inhalation (no more than 30 minutes after randomization) at a ventilation rate of 10L/ min using a sealed non-ventilating oxygen storage mask and keep giving oxygen for 4 hours. If the patient needs to be intubated with a ventilator to maintain ventilation, the FiO2 should be set to 1.0.
Nasal oxygen
For nasal oxygen group, Patients were immediately given oxygen inhalation (no more than 30 minutes after randomization) at a ventilation rate of 1L/min using nasal cannula and keep giving oxygen for 4 hours. If the patient needs to be intubated with a ventilator to maintain, the FiO2 should be set to 0.3 and gradualy incerased if spO2≤94%.
Intravenous thrombolysis(rt-PA)
10% dose of rt-PA (0.9 mg/kg) is given as bolus and the rest given as an infusion over the remaining 1 hour. Maximum dose 90mg.
RECRUITING
Xuan Wu Hospital，Capital Medical University, Beijing
Beijing Friendship Hospital
OTHER
Beijing Shijitan Hospital, Capital Medical University
OTHER
Beijing Tongren Hospital
OTHER
People's Hospital of Beijing Daxing District
OTHER
Tianjin Huanhu Hospital
OTHER
Guizhou Provincial People's Hospital
OTHER
Shandong Provincial Hospital
OTHER_GOV
The First Affiliated Hospital of Soochow University
OTHER
The First Affiliated Hospital of Zhengzhou University
OTHER
The Affiliated Hospital of Xuzhou Medical University
OTHER
Jining First People's Hospital
OTHER
Linyi People's Hospital
OTHER
Nanyang Central Hospital
OTHER
Rizhao People's Hospital
OTHER
Zhumadian Central Hospital
OTHER
Second Affiliated Hospital of Nanchang University
OTHER
Affiliated Hospital of Nantong University
OTHER
The Second Hospital of Anhui Medical University
OTHER
Changsha Central Hospital
OTHER
Ji Xunming,MD,PhD
OTHER