The Genital Microbiome of Male Partners of Women with Recurrent BV Undergoing Vaginal Microbiome Transplantation

NARecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

October 17, 2022

Primary Completion Date

December 31, 2025

Study Completion Date

June 30, 2026

Conditions
Bacterial VaginosisMicrobial Colonization
Interventions
OTHER

chlorhexidine gluconate 4%

"In case BV associated bacteria will be identified (using molecular sequencing) in male samples, decolonization attempt will be conducted, using a daily wash for 5 days with chlorhexidine gluconate 4%. Following decolonization attempt, male participants will undergo re- sampling, to assess for microbiome changes.~In case there is no change in microbial composition, partners will be instructed to repeat decolonization protocol, and apply a 2 cm diameter volume of 2% clindamycin cream topically to the head of the penis and upper shaft (under the foreskin if uncircumcised) twice daily for seven days following repeated decolonization. Re-sampling will follow."

Trial Locations (1)

Unknown

RECRUITING

Hadassah Medical Center, Jerusalem

All Listed Sponsors
lead

Hadassah Medical Organization

OTHER