Transapical Beating-Heart Septal Myectomy in Patient With Hypertrophic Obstructive Cardiomyopathy: a Multi-Center Study

NARecruitingINTERVENTIONAL
Enrollment

1,000

Participants

Timeline

Start Date

July 31, 2023

Primary Completion Date

July 31, 2025

Study Completion Date

October 31, 2025

Conditions
Hypertrophic Obstructive Cardiomyopathy
Interventions
PROCEDURE

Transapical beating-heart septal myectomy

We have invented a beating-heart myectomy device.Through a minimally invasive intercostal incision, septal myectomy could be accomplished via a transapical access in the beating heart using the device. The whole process of resection is monitored, navigated, and evaluated by real-time transesophageal and transthoracic echocardiography. Left ventricle outlet tract gradient and the grade of mitral regurgitation are evaluated each time after resection. Multiple resections are performed to tailor the muscular resection for sufficient relief of left ventricle outlet tract obstruction and mitral regurgitation, while preventing iatrogenic injuries.

Trial Locations (1)

430000

RECRUITING

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

All Listed Sponsors
collaborator

Guangdong Provincial People's Hospital

OTHER

collaborator

Beijing Anzhen Hospital

OTHER

collaborator

Fudan University

OTHER

collaborator

Second Hospital of Jilin University

OTHER

lead

Xiang Wei

OTHER