Dissecting the Cellular and Molecular Atlas of Rheumatoid Arthritis in Sustained Remission to Identify Pathways Maintaining Remission and Triggering Flares

RecruitingOBSERVATIONAL
Enrollment

130

Participants

Timeline

Start Date

July 11, 2023

Primary Completion Date

May 10, 2026

Study Completion Date

May 10, 2026

Conditions
Rheumatoid Arthritis
Interventions
OTHER

Tapering and/or discontinuation of treatment based on AI-guidance

After synovial tissue biopsy, pharmacological treatment (cDMARDs or bDMARDs) are tapered first and then bDMARDs and/or cDMARDs are discontinued based on AI-guidance

OTHER

No tapering and/or discontinuation of treatment based on AI-guidance

Ongoing therapeutic are not changed (tapered or discontinued) after synovial biopsy performance based on AI-guidance

OTHER

Tapering and/or discontinuation of treatment based on standard of care

After synovial tissue biopsy, pharmacological treatment (cDMARDs or bDMARDs) are tapered first and then bDMARDs and/or cDMARDs are discontinued based on standard of care

OTHER

No tapering and/or discontinuation of treatment based on standard of care

Ongoing therapeutic are not changed (tapered or discontinued) after synovial biopsy performance based on standard of care

Trial Locations (4)

00168

RECRUITING

Division of Rheumatology, Rome

Unknown

NOT_YET_RECRUITING

Hospital Clinic and Fundació Clinic per la Recerca Biomèdica, Barcelona

ACTIVE_NOT_RECRUITING

Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), Glasgow

ACTIVE_NOT_RECRUITING

Newcastle University, Newcastle upon Tyne

All Listed Sponsors
collaborator

University of Glasgow

OTHER

collaborator

Fundacion Clinic per a la Recerca Biomédica

OTHER

collaborator

Newcastle University

OTHER

lead

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

OTHER