A Study to Investigate Efficacy and Safety of BCL2 Inhibitor Sonrotoclax as Monotherapy and in Combination With Zanubrutinib in Adults With Waldenström Macroglobulinemia

PHASE2RecruitingINTERVENTIONAL
Enrollment

105

Participants

Timeline

Start Date

September 28, 2023

Primary Completion Date

December 31, 2026

Study Completion Date

August 31, 2028

Conditions
Waldenstrom MacroglobulinemiaWaldenstrom's Macroglobulinemia RecurrentWaldenstrom's Macroglobulinemia Refractory
Interventions
DRUG

Sonrotoclax

Administered orally as a tablet.

DRUG

Zanubrutinib

Administered orally as a capsule.

Trial Locations (72)

8036

RECRUITING

Hospital Clinic de Barcelona, Barcelona

8221

RECRUITING

Hospital Universitari Mutua Terrassa, Terrassa

13009

RECRUITING

Institut Paoli Calmettes, Marseille

20141

RECRUITING

Istituto Europeo Di Oncologia, Milan

20162

RECRUITING

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan

23298

COMPLETED

Virginia Commonwealth University Massey Cancer Center, Richmond

25123

RECRUITING

Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia, Brescia

27100

RECRUITING

Irccs Policlinico San Matteo, Universita Degli Studi Di Pavi, Pavia

28040

RECRUITING

Hospital Universitario Fundacion Jimenez Diaz, Madrid

33100

RECRUITING

Azienda Sanitaria Universitaria Friuli Centrale Presidio Ospedaliero Universitario Santa Maria Del, Udine

37007

RECRUITING

Hospital Universitario de Salamanca, Salamanca

40138

RECRUITING

Irccs Azienda Ospedaliero Universitaria Bologna, Bologna

41013

RECRUITING

Hospital Universitario Virgen Del Rocio, Seville

50263

COMPLETED

Mission Cancer and Blood, Waukee

51100

RECRUITING

Hopital Robert Debre, Reims

63100

RECRUITING

Chu Clermont Ferrand Therapie Cellulaire and Hematolo, Clermontferrand

69495

RECRUITING

Chu Hopital Lyon Sud, PierreBenite

75013

RECRUITING

Hopital de La Pitie Salpetriere, Paris

80054

RECRUITING

Centre Hospitalier Universitaire Damiens Hopital Sud, Amiens

80218

RECRUITING

Colorado Blood Cancer Institute, Denver

98195

RECRUITING

University of Washington, Seattle

110134

RECRUITING

Shengjing Hospital of China Medical Universityshenbei Branch, Shenyang

200032

RECRUITING

Affiliated Zhongshan Hospital of Fudan University, Shanghai

224006

RECRUITING

Yancheng First Peoples Hospital, Yancheng

266000

RECRUITING

The Affiliated Hospital of Qingdao University Branch South, Qingdao

300020

RECRUITING

Institute of Hematology and Hospital of Blood Disease, Tianjin

310003

RECRUITING

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

314001

RECRUITING

The First Hospital of Jiaxing, Jiaxing

325000

RECRUITING

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

361003

RECRUITING

The First Affiliated Hospital of Xiamen University, Xiamen

430030

RECRUITING

Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan

450000

RECRUITING

Henan Cancer Hospital, Zhengzhou

510080

RECRUITING

Guangdong Provincial Peoples Hospital, Guangzhou

91010-3012

RECRUITING

City of Hope National Medical Center, Duarte

20007-2113

COMPLETED

Medstar Georgetown University Hospital, Washington D.C.

33136-2107

RECRUITING

University of Miami, Miami

60555-3269

RECRUITING

Northwestern Medicine Cancer Center, Warrenville

21201-1544

COMPLETED

University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore

02215-5418

RECRUITING

Dana Farber Cancer Institute, Boston

55905-0001

RECRUITING

Mayo Clinic Rochester, Rochester

39401-7233

COMPLETED

Hattiesburg Hematology and Oncology Clinic, Hattiesburg

10065-6800

RECRUITING

Memorial Sloan Kettering Cancer Center Mskcc, New York

28204-2990

RECRUITING

Atrium Health Levine Cancer Institute (Lci), Charlotte

43210-1280

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

75390-7208

COMPLETED

Ut Southwestern Medical Center, Dallas

84112-5550

RECRUITING

Huntsman Cancer Institute, Salt Lake City

NSW 2139

RECRUITING

Concord Repatriation General Hospital, Concord

NSW 2065

RECRUITING

Genesiscare North Shore, St Leonards

QLD 4102

RECRUITING

Princess Alexandra Hospital, Woolloongabba

SA 5042

RECRUITING

Flinders Medical Centre, Bedford PK

VIC 3168

RECRUITING

Monash Health, Clayton

VIC 3065

RECRUITING

St Vincents Hospital Melbourne, Fitzroy

WA 6009

RECRUITING

Linear Clinical Research, Nedlands

WA 6000

RECRUITING

Royal Perth Hospital, Perth

T6G 1Z2

COMPLETED

Cross Cancer Institute, Edmonton

V7L 2L7

COMPLETED

Lions Gate Hospital Chemotherapy Clinic, North Vancouver

B3H 2Y9

COMPLETED

Qeii Health Science Center, Halifax

M5G 2M9

COMPLETED

Princess Margaret Cancer Centre, Toronto

037008

RECRUITING

The Third Peoples Hospital of Datong, Datong

115 28

RECRUITING

General Hospital of Athens Alexandra, Athens

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli, Roma

08035

RECRUITING

Hospital Universitario Vall Dhebron, Barcelona

08908

RECRUITING

Institut Catala Doncologia, Barcelona

BH7 7DW

RECRUITING

University Hospitals Dorset, Bournemouth

G12 0YN

RECRUITING

Beatson West of Scotland Cancer Centre, Glasgow

OX3 7LE

RECRUITING

Churchill Hospital Oxford University Hospital Nhs Trust, Headington

IV2 3BW

RECRUITING

Nhs Highland, Inverness

LS9 7TF

RECRUITING

St Jamess University Hospital, Leeds

NW1 2PG

RECRUITING

University College Hospital, London

M20 4BX

RECRUITING

The Christie Nhs Foundation Trust Manchester, Manchester

PL6 8DH

RECRUITING

Plymouth Hospitals Nhs Trust, Plymouth

SM2 5PT

RECRUITING

Royal Marsden Nhs Foundation Royal Marsden Hospital, Sutton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY