A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).

PHASE3RecruitingINTERVENTIONAL
Enrollment

720

Participants

Timeline

Start Date

August 8, 2023

Primary Completion Date

March 14, 2035

Study Completion Date

March 14, 2035

Conditions
Leukemia, Lymphocytic, Chronic, B-CellLeukemia, Chronic LymphocyticSmall-Cell LymphomaLymphoma, Small LymphocyticCLLSLL
Interventions
DRUG

Nemtabrutinib

5 and 20 mg tablets

DRUG

Venetoclax

10, 50, and 100 mg tablets

BIOLOGICAL

Rituximab

100 mg/10 mL, 500 mg/50 mL (10 mg/mL) IV Infusion

Trial Locations (52)

1414

RECRUITING

Centro Medico Fleischer ( Site 1006), Buenos Aires

2030

RECRUITING

ZAS Cadix ( Site 1203), Antwerp

3000

RECRUITING

UZ Leuven-Hematology ( Site 1200), Leuven

3021

RECRUITING

Western Health-Sunshine & Footscray Hospitals-Cancer Services-Cancer Research ( Site 1103), Melbourne

5000

RECRUITING

Royal Adelaide Hospital ( Site 1104), Adelaide

7580

RECRUITING

Haemalife ( Site 4407), Kuilsriver

7925

RECRUITING

Groote Schuur Hospital ( Site 4400), Cape Town

15121

RECRUITING

Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo ( Site 2906), Alessandria

20132

RECRUITING

Ospedale San Raffaele-Programma di Ricerca Strategica sulla LLC ( Site 2902), Milan

28223

RECRUITING

HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 4602), Pozuelo de Alarcón

33028

RECRUITING

Memorial Hospital West ( Site 5410), Pembroke Pines

34214

RECRUITING

Mega Medipol-Hematology ( Site 4904), Istanbul

34722

RECRUITING

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi ( Site 4906), Istanbul

35100

RECRUITING

Ege Universitesi Hastanesi ( Site 4902), Izmir

42123

RECRUITING

Arcispedale Santa Maria Nuova-Hematology ( Site 2900), Reggio Emilia

46010

RECRUITING

HOSPITAL CLINICO DE VALENCIA-HEMATOLOGY ( Site 4603), Valencia

53792

RECRUITING

University of Wisconsin Hospital and Clinics-Carbone Cancer Center ( Site 5423), Madison

54290

RECRUITING

Klinikum Mutterhaus der Borromäerinnen-Innere Medizin I ( Site 2203), Trier

58260

RECRUITING

Centro de Investigacion Clinica Chapultepec ( Site 3309), Morelia

59037

RECRUITING

Hopital Claude Huriez - CHU de Lille ( Site 2107), Lille

59100

RECRUITING

Namik Kemal University Medical Faculty-Hematology ( Site 4912), Tekirdağ

63100

RECRUITING

Centre Hospitalier Universitaire Estaing ( Site 2105), Clermont-Ferrand

72762

RECRUITING

Highlands Oncology Group ( Site 5405), Springdale

85925

RECRUITING

CHD Vendee ( Site 2100), La Roche-sur-Yon

90806

RECRUITING

MemorialCare Health System - Long Beach Medical Center ( Site 5421), Long Beach

99208

RECRUITING

Medical Oncology Associates, PS ( Site 5406), Spokane

760032

RECRUITING

Fundación Valle del Lili ( Site 1703), Santiago de Cali

1720430

RECRUITING

IC La Serena Research ( Site 1506), La Serena

3109601

RECRUITING

Rambam Health Care Campus ( Site 2801), Haifa

4070196

RECRUITING

Biocenter ( Site 1507), Concepción

5265601

RECRUITING

Sheba Medical Center-Hemato Oncology ( Site 2809), Ramat Gan

6423906

RECRUITING

Sourasky Medical Center ( Site 2811), Tel Aviv

7500653

RECRUITING

Centro de Estudios Clínicos SAGA-CECSAGA ( Site 1509), Santiago

7500921

RECRUITING

FALP-UIDO ( Site 1500), Santiago

7580206

RECRUITING

Clínica Inmunocel ( Site 1511), Santiago

9112001

RECRUITING

Hadassah Medical Center-Hemato-Oncology ( Site 2812), Jerusalem

97239-3011

RECRUITING

Oregon Health and Science University ( Site 5425), Portland

C1426ANZ

RECRUITING

Instituto Alexander Fleming ( Site 1005), Ciudad Autónoma de Buenos Aires

B7600FZO

RECRUITING

Instituto de Investigaciones Clínicas Mar del Plata ( Site 1007), Mar del Plata

S2000DVC

RECRUITING

Sanatorio Parque ( Site 1003), Rosario

C1118AAT

RECRUITING

Hospital Aleman-oncohematologic diseases ( Site 1001), Buenos Aires

01246-000

ACTIVE_NOT_RECRUITING

ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO-Pesquisa Clinica ( Site 1308), São Paulo

E1C 6Z8

RECRUITING

The Moncton Hospital ( Site 1414), Moncton

04103

RECRUITING

Universitätsklinikum Leipzig-Medical Department I - Hematology and Celltherapy ( Site 2201), Leipzig

03100

RECRUITING

Centro de Infusion Superare ( Site 3314), Mexico City

RECRUITING

Health Pharma Professional Research S.A. de C.V: ( Site 3301), Mexico City

00918

RECRUITING

Auxilio Mutuo Cancer Center ( Site 3900), San Juan

0181

RECRUITING

Netcare Pretoria East Hospital-Albert Alberts Stem Cell Transplant Centre ( Site 4401), Moreletapark

08908

RECRUITING

Instituto Catalan de Oncologia - Hospital Duran i Reynals-Haematology Department ( Site 4601), L'Hospitalet Del Llobregat

06100

RECRUITING

Ankara Universitesi Tip Fakultesi Hastanesi-hematology ( Site 4913), Ankara

NG5 1PF

RECRUITING

City Hospital, Nottingham University Hospitals-Hematology ( Site 5002), Nottingham

NW1 2PG

RECRUITING

University College London Hospital-Cancer Clinical Trials Unit ( Site 5001), London-Camden

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY