taVNS Paired With Motor Training for Upper-extremity Rehabilitation in Stroke Patients

NARecruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

August 1, 2023

Primary Completion Date

July 1, 2025

Study Completion Date

December 1, 2025

Conditions
Upper Extremity DysfunctionStroke
Interventions
DEVICE

paired taVNS

The stimulator will be placed on the left ear of the patient. While the patient performs the action training, the EMG signal feature evoked by the action will trigger an electrical stimulation of the transcutaneous auricular vagus nerve. The amplitude of the electrical stimulation will be adjusted under the patient's pain threshold. The intervention will be performed daily for 14 days.

DEVICE

Unpaired taVNS

The stimulator will be placed on the patient's left ear. Patients will receive taVNS with pulses every 5-7 seconds. Following the stimulation, motor training will be performed. The motor training will be identical to that of the paired group. The amplitude of the electrical stimulation will be adjusted under the patient's pain threshold. The intervention will be performed daily for 14 days.

DEVICE

Sham taVNS

The stimulator will be placed on the patient's left ear. The amplitude of the electrical stimulation will be adjusted at 0 mA. The intervention will be performed daily for 14 days.

Trial Locations (1)

510280

RECRUITING

Zhujiang Hospital of Southern Medical University, Guangzhou

All Listed Sponsors
collaborator

Zhuhai Fudan Innovation Institute

UNKNOWN

collaborator

BrainClos Co., LTD.

UNKNOWN

lead

Qiuyou Xie

OTHER