NCT05935280View on ClinicalTrials.gov

Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8

EARLY_PHASE1CompletedINTERVENTIONAL
Enrollment

36

Participants

Timeline

Start Date

July 7, 2023

Primary Completion Date

September 1, 2023

Study Completion Date

September 1, 2023

Conditions
Pain
Interventions
OTHER

Room temperature

Room temperature injection

OTHER

Cold temperature

Cold temperature injection

DRUG

Lidocain

Unspecific sodium channel blocker

DRUG

PF-05105679

Specific antagonist of the TRPM8 ion channel

DRUG

A967079

Specific antagonist of the TRPA1 ion channel

DRUG

PF-05089771

Specific antagonist of the Nav1.7 sodium channel

DRUG

PF-06305591

Specific antagonist of the Nav1.8 sodium channel

Trial Locations (1)

1090

Medical University of Vienna, Vienna

All Listed Sponsors
lead

Medical University of Vienna

OTHER