Deciphering the Vitiligo Transcriptomic Signature Between Repigmented and Non Repigmented Lesions

"At baseline: one 4 mm Ø skin biopsies: on forearms (excluding skin folds): fresh At month 3 and month 6: Two 4 mm Ø skin biopsies will be performed on the same lesion selected at baseline (one on a repigmented area, one on a non-responded area): fresh~Fresh Skin biopsies will be analyzed the same day using Single-cell RNA sequencing (scRNAseq)."

Blood samples will be taken (30 mL) at week 0, week 12, week 24 for the measurement of pro-inflammatory cytokines and chemokines ligands in blood sera.

narrowband UVB (Nb-UVB) 2 times a week

Oral minipuls of systemic steroids (Medrol 16mg twice a week) for 24 weeks