Clinical Phenotypes in Pericarditis: IL-1RA Antibodies and suPAR Levels

RecruitingOBSERVATIONAL
Enrollment

146

Participants

Timeline

Start Date

July 1, 2023

Primary Completion Date

July 1, 2025

Study Completion Date

December 20, 2025

Conditions
Pericarditis
Interventions
DIAGNOSTIC_TEST

IL1RA Antibody Assay

-The measurement of anti-interleukin-1 receptor antagonist (IL1RA) antibodies will be performed using the ELISA (Enzyme-Linked Immunosorbent Assay) method,as previously described \[Thurner, L., et al., IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination. N Engl J Med, 2022. 387(16): p. 1524-1527\].

DIAGNOSTIC_TEST

suPAR Testing

"-The quantitative determination of soluble urokinase plasminogen activator receptor (suPAR) levels in blood will be conducted using the commercially available CHORUS suPAR Extended kit (cod. 81414, DIESSE Diagnostica Senese S.p.A., Siena, Italy), based on the principle of the sandwich ELISA method."

Trial Locations (9)

20157

RECRUITING

Luigi Sacco Hospital - ASST Fatebenefratelli Sacco, Milan

Unknown

RECRUITING

Saarland University, Homburg

NOT_YET_RECRUITING

University Children's Hospital Muenster, Münster

NOT_YET_RECRUITING

University Hospital Tübingen, Tübingen

NOT_YET_RECRUITING

A.O.U. Careggi, Florence

RECRUITING

Fatebenefratelli Hospital - ASST Fatebenefratelli Sacco, Milan

NOT_YET_RECRUITING

Ospedale Galeazzi Sant'Ambrogio - IRCCS, Poliambulatorio Cardiovascolare Cardiologia Universitaria, Milan

NOT_YET_RECRUITING

Policlinico di Milano Ospedale Maggiore, Fondazione IRCCS Ca' Granda, Milan

NOT_YET_RECRUITING

Ospedale Santa Maria della Misericordia dell'ASU-FC, Udine

All Listed Sponsors
collaborator

Fatebenefratelli Hospital

OTHER

collaborator

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

OTHER

collaborator

Ospedale Galeazzi Sant'Ambrogio - IRCCS

UNKNOWN

collaborator

Careggi Hospital

OTHER

collaborator

Azienda Ospedaliero Universitaria, Santa Maria della Misericordia di Udine, Italy

OTHER

collaborator

Children's Medical Hospital, University of Muenster, Muenster, Germany

OTHER

collaborator

University of Homburg

OTHER

collaborator

University Hospital Tuebingen

OTHER

lead

ASST Fatebenefratelli Sacco

OTHER