Effect of APRV vs. LTV on Right Heart Function in ARDS Patients: a Single-center Randomized Controlled Study

NACompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

July 3, 2023

Primary Completion Date

February 1, 2025

Study Completion Date

February 1, 2025

Conditions
Right Heart FailureMechanical VentilationAcute Respiratory Distress Syndrome
Interventions
PROCEDURE

Airway pressure release ventilation

ventilator parameters were set according to the study protocol, P high: Tidal volume (VT) was set at 6ml/kg of ideal body weight, and plateau pressure (Pplat) was measured. Initial Phigh was set at Pplat, usually 20-32 cmH2O. The APRV end-expiratory flow rate was set at 75% of the peak expiratory flow rate.

PROCEDURE

low tidal volume

The ARDSnet method was used for LTV mechanical ventilation, and the tidal volume was set according to 4-8ml/kg, so that the Pplat was \<30cmH2O

Trial Locations (1)

430000

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

All Listed Sponsors
lead

XiaoJing Zou,MD

OTHER