NCT05919992 - The Role of Glucocorticoids to Maintain Energy Homeostasis During Starvation (Gluco-Starve) | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

May 15, 2023

Primary Completion Date

July 25, 2024

Study Completion Date

July 25, 2024

Conditions

Glucocorticoid Effect

Interventions

DRUG

Metyrapone 250 mg Oral Tablets

During one phase of the study: Metyrapone (pills of 250mg) on empty stomach: Day 1 0-1-1, day 2 1-2-2, day 3 2-3-3 day 4 3-4-4 day 5 4-4-4 day 6 4-4-4 day 7 4-0-0

DRUG

Hydrocortisone 19.9mg s.c., pulsatile with a flow rate of 10μl/s

Hydrocortisone will be delivered subcutaneously via a pump in a pulsed fashion with a flow rate of 10μl/s from day 1 to day 7 in a total daily dose of 19.9mg

DRUG

Placebo 250 mg Tablets

During another phase of the study: identical looking placebo pills starting Day 1 0-1-1, day 2 1-2-2, day 3 2-3-3 day 4 3-4-4 day 5 4-4-4 day 6 4-4-4 day 7 4-0-0

DRUG

Placebo (0,9% NaCl solution)

Placebo (0,9% NaCl solution) 19.9 mg/d subcutaneously via a pump in a pulsed fashion with a flow rate of 10μl/s from day 1 to day 7

Trial Locations (1)

4031

University Hospital Basel, Basel

All Listed Sponsors

lead

Eleonora Seelig

OTHER