Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution ( IMEMPRO )

NARecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

June 27, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

January 31, 2026

Conditions
ICU Acquired WeaknessMuscle AtrophyEnergy Malnutrition ProteinQuality of LifeMorphological and Microscopic FindingsMetabolic Disturbance
Interventions
DIETARY_SUPPLEMENT

Dietary Supplement: additional substitution of protein

"Day one (admission) no nutrition is applied.~Protein target is increased as follows:~* to a level of 1,2g/kg/d on day 1 after ICU admission~* to a level of 1,4g/kg/d on day 2 after ICU admission~* to a level of 1,6g/kg/d on day 3 after ICU admission~* to a level of 1,8g/kg/d on day 4 after ICU admission~* to a level of 2,0g/kg/d from day 5 onwoards~Additional protein is given within 2 hours after mobilization respectively:~* to 0,125g/kg/d on day 1 after ICU admission~* to 0,2g/kg/d on day 2 after ICU admission~* to 0,25g/kg/d on day 3 after ICU admission~* to 0,3g/kg/d from day 4 after ICU admission onwoards"

DEVICE

Neuromuscular electrical stimulation

twice daily 60 minutes till day 28 or ICU discharge

OTHER

Early Mobilization

at least 20 minutes a day following the SOMS concept. Duration: till 28 day or ICU discharge

Trial Locations (4)

1090

RECRUITING

Medical University of Vienna, Vienna

10117

RECRUITING

Charité - Universitätsmedizin Berlin, Berlin

81675

ACTIVE_NOT_RECRUITING

Klinikum rechts der Isar, School of Medicine, Technical Universtity of Munich, Munich

89070

RECRUITING

Universitätsklinikum Ulm, Ulm

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Fresenius Kabi

INDUSTRY

collaborator

University Medicine Greifswald

OTHER

collaborator

Berlin Institute of Health

OTHER

collaborator

Universitätsklinikum Ulm

UNKNOWN

collaborator

Medical University of Vienna

OTHER

lead

Technical University of Munich

OTHER

NCT05919940 - Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution ( IMEMPRO ) | Biotech Hunter | Biotech Hunter