Effectiveness of Mycophenolate Mofetil Combined With Tacrolimus for Steroid Tapering in Systemic Lupus Erythematosus

PHASE4RecruitingINTERVENTIONAL
Enrollment

220

Participants

Timeline

Start Date

July 1, 2023

Primary Completion Date

July 31, 2025

Study Completion Date

July 31, 2026

Conditions
Systemic Lupus ErythematosusLupus Nephritis
Interventions
DRUG

Mycophenolate Mofetil

"Participants in steroid tapering group will take MMF+TAC during the first 18 months. After 18 months, participants without lupus flare will randomly stop MMF or TAC.~Participants in steroid maintenance group will take MMF+TAC during the first 24 months. After 24 months, participants without lupus flare will randomly stop MMF or TAC."

DRUG

Tacrolimus

"Participants in steroid tapering group will take MMF+TAC during the first 18 months. After 18 months, participants without lupus flare will randomly stop MMF or TAC.~Participants in steroid maintenance group will take MMF+TAC during the first 24 months. After 24 months, participants without lupus flare will randomly stop MMF or TAC."

DRUG

Glucocorticoid

"Participants in steroid tapering group will stop taking glucocorticoid after the first 6 months.~Participants in steroid maintenance group will consistently take glucocorticoid for 18 months, and stop the use of glucocorticoid after 18 months if they do not flare."

Trial Locations (1)

100730

RECRUITING

Peking Union Medical College Hospital, Beijing

All Listed Sponsors
collaborator

Peking Union Medical College Hospital

OTHER

lead

Chinese SLE Treatment And Research Group

OTHER