500
Participants
Start Date
October 1, 2023
Primary Completion Date
January 1, 2027
Study Completion Date
December 30, 2027
Randomization to either Amphetamine (AMP) class of stimulant medication or Methylphenidate (MPH) class of stimulant medication
"Amphetamine (AMP) medication names: Adderall, Adderall XR, Adzenys ER, Adzenys XR-ODT, Dayanavel XR, Dexedrine (spansule), Dexedrine (tablet), Mydayis, Procentra liquid~Methylphenidate (MPH) medication names: Adhansia XR, Aptensio XR, Azstarys, Concerta, Cotempla XR-ODT, Daytrana, Focalin, Focalin XR, Jornay PM. Metadate CD, Methylin (liquid), Ritalin, Ritalin LA, Quillichew ER, Quillivant XR (liquid)"
Randomization to either Alpha 2 agonist class of medication or alternate class of stimulant.
"If first line stimulant therapy (Amphetamine/Methylphenidate) is deemed not effective or tolerable, re-randomization to the alternate stimulant or alpha-2 agonist will occur. If participant is satisfied with first line stimulant treatment, first-line stimulant therapy will continue.~Catapres, Clonidine, Guanfacine, Intuniv, Kapvay, Tenex"
RECRUITING
University of Rochester, Rochester
RECRUITING
University of Pittsburgh, Pittsburgh
RECRUITING
Children's Hospital of Philadelphia, Philadelphia
RECRUITING
University of Virginia, Charlottesville
RECRUITING
Nationwide Children's Hospital, Columbus
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
RECRUITING
Children's Hospital Los Angeles, Los Angeles
RECRUITING
University of California, Irvine, Irvine
RECRUITING
Maine Medical Center, Portland
RECRUITING
Massachusetts General Hospital Lurie Center for Autism, Boston
RECRUITING
University of Alberta, Glenrose Rehabilitation Hospital, Edmonton
RECRUITING
Holland Bloorview Kids Rehabilitation Hospital, Toronto
Collaborators (1)
Patient-Centered Outcomes Research Institute
OTHER
University of California, Irvine
OTHER
Holland Bloorview Kids Rehabilitation Hospital
OTHER
Children's Hospital of Philadelphia
OTHER
University of Rochester
OTHER
Nationwide Children's Hospital
OTHER
Children's Hospital Medical Center, Cincinnati
OTHER
University of Pittsburgh
OTHER
Children's Hospital Los Angeles
OTHER
University of Virginia
OTHER
University of Alberta
OTHER
Massachusetts General Hospital
OTHER
MaineHealth
OTHER
University of Michigan
OTHER
Daniel Coury
OTHER